摘要
目的采用Meta分析系统评价隔物灸治疗膝骨关节炎的临床疗效与安全性。方法计算机检索中国知网(CNKI)、维普数据库(VIP)、万方数据库(WANGFANG DATA)、Pubmed、Cochrane临床对照试验中心注册库(2016年6期),所有数据库检索时间从建库至2016年7月16日。按纳入与排除标准筛选文献,评价文献质量,提取资料,并用Rev Man5.2软件对数据进行Meta分析。结果初步检索出文献766篇文献,最终纳入10篇文献。合计病例866例,治疗组434例,对照组432例。治疗组以隔物灸或隔物灸治疗为主。治疗组有效401例,总有效率为92.61%;对照组有效341例,有效率79.49%,治疗组有效率明显优于对照组,有1篇文献报道了不良反应。异质性检验(χ2=4.68,P>0.1,I2≤50%),数据具有同质性,以固定效应模式进行分析。隔物灸治疗组和对照组合并后效应量为OR=3.26,95%CI(2.12,5.02);合并后效应量的检验Z=5.37(P<0.00001),差异具有统计学意义。结论隔物灸治疗膝骨关节炎安全有效。但纳入文献质量不高,样本量不大,建议开展大样本、多中心、双盲的随机对照试验加以验证。
Objective： To analysis the efficacy and safety of indirect moxibustion on knee osteoarthritis. Meth- otis： A computer-based search was conducted on the CNKI database,VIP database,Wanfang database,Pubmed database, Cochrane Central Register of Controlled Trials （Issue 6,2016）. The time limitation ranged from the com- mencement of each database to July 16,2016. According to selection and elimination principle ,literature was se- lected and evaluated, and date was meta-analyzed with RevMan5.2 statistical software after the literatures were e- valuated. Results： A total 766 articles were found, 10 of which were finally included involving 866 cases： 434 cases in the treatment group and 432 cases in the control group. The treatment group was treated with indirect moxibustion. There were 401 effective cases in the treatment group,the effective rate was 92.61%, and 341 effective cases in the control group,the effective rate was 79.49%. The total effective rate in the treatment group was higher than that of the control group and adverse reactions were reported in 1 literature. The heterogeneity test showed that（x^2=4.68 ,P= 0.86〉0.1, F=0% ≤ 50%） the data was homogeneous and the fixed effect model was analyzed. After the treatment group and the control group were combined,the effect size was OR =3.26,95% CI [2.12,5.02 ]. The test value for overall effect was 5.37 （P〈 0.00001 ）. The differences were statistically significant. Conclusion： The indirect moxibustion is effective and safe in treating knee osteoarthritis. However due to low quality and limited size of included studies, further well-designed randomized controlled trails with high quality are still needed to evaluate the beneficial effects.
出处
《中国中医急症》
2017年第5期799-803,共5页
Journal of Emergency in Traditional Chinese Medicine
基金
重庆市科委自然科学基金项目(csct2011jj A10108)
重庆市卫生局中医药科技重点项目(ZY20131024)
关键词
骨关节炎
隔物灸
META
分
析
Osteoarthritis
Indirect moxibustion
Meta-analysis
