摘要
目的:评估心肌梗死患者血清IL-17水平在心肌梗死后心衰及心律失常中的筛选价值。方法:心肌梗死患者入院确诊后通过酶联免疫吸附法(ELISA)对其进行血清IL-17水平检测,对患者进行随访,记录患者心肌梗死后心衰和心率失常的发生情况,比较149例患者梗死后发生心衰(n=48)和心律失常患者(n=49)和仅有心肌梗死患者(n=52)血清IL-17水平的变化;绘制受试者工作特征曲线(ROC)分析IL-17对心肌梗死后心衰和心律失常的筛选价值。结果:心肌梗死后发生心衰者血清IL-17水平[(36.41±10.96)pg·ml^(-1)]和心肌梗死后心律失常者血清IL-17水平[(24.10±8.07)pg·ml^(-1)]显著高于仅有心肌梗死患者[(16.70±7.92)pg·ml^(-1)](P<0.001)。血清IL-17在筛选心肌梗死后心衰和心律失常中的曲线下面积(AUC)分别为0.91和0.771。结论:心肌梗死后出现心衰和心律失常患者血清IL-17水平显著升高;IL-17水平在心肌梗死后心衰发生中具有一定筛选价值,而在心肌梗死后心律失常的筛选中并不理想。
Objective： To investigate the screening value of serum IL-17 levels for occurrence of heart failure or arrhythmia in patients with myocardial infarction. Methods： Serum IL-17 levels were detected by enzyme-linked immunosorbent assay（ ELISA） in 149 patients with myocardial infarction only（ n = 52）,occurrence of heart failure（ n = 48） or arrhythmia（ n = 49）; ROC curve was performed to analyze the screening value of IL-17 for heart failure and arrhythmia in patients with myocardial infarction. Results： Serum levels of IL-17 in patients with heart failure after myocardial infarction [（ 36. 41 ± 10. 96） pg·ml-（-1）]and with arrhythmia after myocardial infarction [（ 24. 10 ±8. 07） pg ·ml-（-1）]were significantly increased than those with myocardial infarction only [（ 16. 70 ± 7. 92） pg·ml-（-1）]（ P 0. 001）. The area under the curve（ AUC） of serum IL-17 in the screening of heart failure and arrhythmia after myocardial infarction were 0. 91 and 0. 771,respectively. Conclusion： Serum levels of IL-17 in patients with heart failure after myocardial infarction and with arrhythmia after myocardial infarction are significantly increased than those with myocardial infarction only. IL-17 presents a certain screening value for occurrence of heart failure after myocardial infarction,while not ideal for screening arrhythmia after myocardial infarction.
出处
《现代医学》
2017年第3期381-384,共4页
Modern Medical Journal
基金
广西科技大学科学基金项目(校科自20161309)
关键词
心肌梗死
白介素-17
心衰
心律失常
筛选价值
myocardial infarction
interleukin-17
heart failure
arrhythmia
screening value
