摘要
目的：研究川芎的化学成分。方法：利用硅胶、大孔吸附树脂、反相C18、Sephadex LH-20柱色谱、制备薄层色谱、半制备高效液相色谱等方法对川芎化学成分进行分离纯化,运用MS、NMR等波谱手段进行结构鉴定。结果：从川芎乙酸乙酯和正丁醇提取物中分离得到了8个化合物,分别鉴定为：苄醇β-D-葡萄糖苷（1）、4-甲氧基-3-羟基苯甲酸（2）、正丁基-β-D-吡喃果糖苷（3）、绿原酸（4）、阿魏酸（5）、5-羟甲基糠醛（6）、α-羟基二十四烷酸（7）、邻苯二甲酸二丁酯（8）。结论：其中,化合物2、3和7为首次从该属植物中分离得到,化合物1-3、7为首次从该植物中分离得到。
Objective：To investigate the chemical constituents of Ligusticum chuanxiong.Methods：The compounds were separated and repeatedly purified by column chromatography by silica gel,macroperous resin,Rp C18 chromatography,and Sephadex LH-20,preparative TLC,and semi-preparative HPLC.Their structures were elucidated by NMR and MS spectroscopic analysis.Results：Eight compounds were isolated from the Et OAc and n-butanol extracts of Ligusticum chuanxiong,and their structures were identified as benzyl β-D-glucopyranoside（1）,4-methoxy-3-hydroxybenzoic acid（2）,n-butyl-β-D-fructopyranoside（3）,chlorogenic acid（4）,ferulic acid（5）,5-hydroxymethyl-2-furfural（6）,α-hydroxytetracosanoic acid（7） and dibutyl phthalate（8）.Conclusion：Compounds 2,3,7 are isolated fromLigusticum genus for the first time,and compounds 1-3 and 7 are isolated from this plant for the first time.
作者
蒲忠慧
蒙春旺
周彦希
彭成
杜旌畅
熊亮
PU Zhong-hui MENG Chun-wang ZHOU Yan-xi PENG Cheng DU Jing-chang XIONG Liang(Pharmacy College, Chengdu University of TCM, The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China College of Life Science and Technology of Mianyang Normal University, Mianyang 621006, China)
出处
《中药材》
CAS
CSCD
北大核心
2016年第11期2529-2531,共3页
Journal of Chinese Medicinal Materials
基金
四川省科技支撑计划(2015SZ0031)
关键词
川芎
化学成分
结构鉴定
Ligusticum chuanxiong Hort.
Chemical constituents
Structure identification
