摘要
人类嗜T细胞病毒(Human T-lymphotropic virus,HTLV)与成人T细胞白血病和热带痉挛性下肢轻瘫/HTLV相关脊髓病密切相关。该病毒主要通过输血、性接触和母婴传播。无偿献血者HTLV筛查是预防其经输血传播有效的方法。欧美等国先后通过成本-效用分析,建立本国无偿献血者HTLV筛查策略。由于我国各地区HTLV流行率和经济情况不同,不同地域的研究人员针对无偿献血者提出了不同的HTLV筛查策略。然而,该策略目前尚无定论。本文对我国各地区和国外的无偿献血者HTLV筛查研究进展进行综述。
Human T-lymphtropic virus （HTLV-1 and HTLV-2） are closely associated with adult T-cell leukemia （ATL） and HTLV-associated myelopathy/tropical spastic paraparesis （HAM/TSP）.Blood transfusion,sexual intercourses and mother to child are main patterns of HTLVs transmission.HTLV screening among blood donors is an effective prevention of transmission of HTLVs through transfusion.A series of cost-effectiveness analysis were performed in Europe and in the United States,which contributes to implementation of HTLV screening among blood donors.Researchers from different areas of China suggest dissimilar strategy because of the discrepancy of HTLV prevalence and economy,which,however,is still unclear.We present an overview of different strategies of HTLV screening among blood donors in different regions of China and other foreign countries.
出处
《中国输血杂志》
北大核心
2017年第3期231-234,共4页
Chinese Journal of Blood Transfusion
