摘要
目的:探讨阿司匹林联合辛伐他汀治疗脑血栓的临床价值。方法:选取2014年7月至2016年3月收治的脑血栓患者96例为研究对象,利用随机数字表法分为观察组与对照组,对照组给予阿司匹林治疗,观察组在对照组基础上加用辛伐他汀治疗,观察2组患者治疗效果、血液流变学指标及不良反应发生情况。结果:观察组治疗总有效率为91.67%,与对照组75.00%比较,差异有统计学意义(P<0.05);治疗前2组患者血液流变学指标差异均无统计学意义(P>0.05),治疗后均有改善,观察组治疗后血浆粘度、红细胞压积及血沉同对照组比较,差异有统计学意义(P<0.05);观察组与对照组不良反应发生率分别为6.25%、20.83%,差异有统计学意义(P<0.05)。结论:脑血栓患者接受阿司匹林联合辛伐他汀治疗,可显著增强疗效,促进血液流变学改善,减少不良反应,值得推广。
Objective： To explore the clinical value of aspirin combined with simvastatin in the treatment of cerebral thrombosis. Methods： A total of 96 cases of patients with cerebral thrombosis from Jul 2014 to Mar 2016 were selected as subjects, and were divided into the observation group and the control group by random number table. The control group were given aspirin, while the observation group were treated with aspirin combined with simvastatin. The curative effect, hemorheology indexes and adverse reactions were observed. Results： The total effective rate of the observation group was 91.67%, which was significantly higher than that of the control group （75.00%） , the difference was statistically significant （P〈0.05） . There was no significant difference in hemorheology indexes between the two groups before treatment （P〉O.05） . After treatment, the plasma viscosity, hematocrit and erythrocyte sedimentation rate （ESR） were significantly lower in the observation group than those in the control group （P〈0.05） . The incidence of adverse reactions in the observation group was 6.25%, which was significantly lower than that in the control group （20.83%, P〈0.05） . Conclusion： Aspirin combined with simvastatin in the treatment of cerebral thrombosis can significantly improve the curative effect, improve hemorheology and reduce adverse reactions, which is worthy of promotion.
出处
《沈阳医学院学报》
2017年第3期237-239,共3页
Journal of Shenyang Medical College
