摘要
目的研究低分子肝素钙联合百令胶囊对过敏性紫癜性肾炎患儿的临床疗效及对血清hs-CRP、MMP-9、APN、CysC的影响。方法选取2013年1月~2015年12月宁波市妇女儿童医院收治的84例过敏性紫癜性肾炎患儿,根据患儿入院顺序分为观察组和对照组,42例每组。对照组使用低分子肝素钙,观察组使用低分子肝素钙联合百令胶囊进行治疗。比较2组患儿临床疗效,血清hs-CRP、MMP-9、APN、CysC水平,炎性因子和免疫水平,不良反应。结果治疗后,观察组临床有效率显著高于对照组[92.86%（39/42）比69.05%（29/42）]（P〈0.05）。治疗前,2组患儿hs-CRP、MMP-9、APN、CysC水平比较无显著差异,治疗后,2组患儿hsCRP、MMP-9、CysC水平较治疗前显著降低（P〈0.05）,APN较治疗前显著升高（P〈0.05）,和对照组相比,观察组的hs-CRP、MMP-9、CysC水平较低（P〈0.05）,APN水平较高（P〈0.05）。治疗前,2组患儿TNF-α、IL-6、IL-10、IL-18水平比较无显著差异,治疗后,2组患儿TNF-α、IL-6、IL-18水平较治疗前显著降低（P〈0.05）,IL-10水平较治疗前显著升高（P〈0.05）,和对照组相比,观察组的TNF-α、IL-6、IL-18水平较低（P〈0.05）,IL-10水平较高（P〈0.05）。治疗前,2组患儿IgA、IgG、IgM水平比较差异无统计学意义,治疗后,2组患儿IgA、IgG、IgM水平较治疗前显著降低（P〈0.05）,和对照组相比,观察组的IgA、IgG、IgM水平较低（P〈0.05）。2组患儿不良反应率比较差异无统计学意义。结论低分子肝素钙联合百令胶囊能有效降低过敏性紫癜性肾炎患儿的hs-CRP、MMP-9、CysC水平,APN水平,改善患儿临床症状,临床疗效良好,安全性高。
Objective To study the effect of low molecular weight heparin calcium combined with Bailing capsule in treatment of children with Henoch-Schonlein purpura nephritis and the efficacy of serum hs-CRP, MMP-9, APN and CysC.MethodsFrom January 2013 to December 2015, 84 children with Henoch-Schonlein purpura nephritis were enrolled in our hospital.According to the order of admission, the observation group and control group were divided into observation group and control group.The control group were given low molecular weight heparin calcium, the observation group were treated with low molecular weight heparin calcium combined with Bailing capsule for treatment.The levels of serum hs-CRP, MMP-9, APN, CysC, inflammatory factors and immune levels were observed in the two groups.ResultsAfter treatment, the clinical effective rate of the observation group was significantly higher than that of the control group[92.86% （39/42） vs 69.05% （29/42）] （P〈0.05）.There were no significant differences in hs-CRP, MMP-9, APN and CysC levels between the two groups.After treatment, the levels of hs-CRP, MMP-9 and CysC in the two groups were significantly higher than those before treatment （P〈0.05）.APN was significantly higher than that before treatment （P〈0.05）.Compared with the control group, the levels of hs-CRP, MMP-9 and CysC in the observation group were lower than those in the control group （P〈0.05）, and the APN level was lower than that in the control group （P〈0.05）.There were no significant differences in TNF-α, IL-6, IL-10 and IL-18 levels between the two groups before treatment.After treatment, The levels of TNF-α, IL-6 and IL-18 in the two groups were significantly lower than those before treatment （P〈0.05）.There were no significant differences in IgA, IgG and IgM levels between the two groups.After treatment, the levels of IgA, IgG and IgM in the two groups were significantly lower than those before treatment （P〈0.05）.The levels of IgA, IgG and IgM in the observation group were lower than those in the control group （P〈0.05）.There was no significant difference in adverse reaction rate between the two groups.ConclusionLow molecular weight heparin combined with Bailing capsule can effectively reduce hs-CRP, MMP-9, CysC level and APN level in children with Henoch-Schonlein purpura nephritis, improve clinical symptoms, good clinical efficacy and high safety.
出处
《中国生化药物杂志》
CAS
2017年第5期106-109,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
低分子肝素钙
百令胶囊
过敏性紫癜性肾炎
疗效
low molecular weight heparin calcium
Bailing capsule
allergic purpura nephritis
Efficacy
