摘要
目的探究术前新辅助化疗不同组织类型局部晚期宫颈癌的临床效果。方法选取2012年3月至2014年3月间福建省肿瘤医院收治的108例局部晚期宫颈癌患者,按照组织学类型分为鳞癌组58例与非鳞癌组50例。两组患者均给予紫杉醇联合顺铂化疗,结束2至3周后进行手术治疗,对比两组患者近期化疗疗效,围术期指标及随访3年生存率、复发率及无瘤生存率。结果鳞癌组患者总有效率为53.4%,非鳞癌组为52.0%,两组相比,差异无统计学意义(P>0.05)。两组患者术中出血量、手术时间、术后住院时间、淋巴结转移率、血管侵犯率及宫旁浸润率相比,差异均无统计学意义(均P>0.05)。鳞癌组患者随访3年生存率、无瘤生存率较非鳞癌组高,复发率较低,差异均有统计学意义(均P<0.05)。结论局部晚期宫颈鳞癌及非鳞癌患者接受术前新辅助化疗的近期疗效相当,且鳞癌患者随访3年的生存率及无瘤生存率明显高于非鳞癌患者。
Objective To probe into efficacy of preoperative neoadjuvant chemotherapy for different tissue types of locally advanced cervical cancer. Methods From March 2012 to March 2014, 108 patients with locally advanced cervical cancer treated at Fujian Tumor Hospital were selected. According to the histo- logical types, patients were divided into squamous carcinoma group （58 patients） and non-squamous carci- noma group （50 patients ）. Both groups were given paclitaxel plus cisplatin chemotherapy. After 2 to 3 weeks, surgery was performed. Recent efficacy of chemotherapy, perioperative indexes and survival rate, recurrence rate and disease-free survival rate after follow up of 3 years were compared between the two groups. Results The overall efficacy rate was 53.4% for squamous carcinoma group and 52. 0% for non- squamous carcinoma group （ P 〉 0. 05 ）. There was no significant difference in intraoperative blood loss, op- erative time, postoperative hospital stay, rate of lymph node metastasis, vascular invasion rate and parame- trial invasion rate between the two groups （ all P 〉 0. 05 ）. Survival rate and disease-free survival rate over the follow-up of 3 years were higher and the recurrence rate was lower in squamous carcinoma group than non-squamous carcinoma group （ all P 〉 0. 05 ）. Conclusion Patients receiving preoperative neoadjuvant chemotherapy in squamous carcinoma group and non-squamous carcinoma group have similar recent effica- cy. However, the survival rate over follow-up of 3 years and disease-free survival rate were significantly higher in in squamous carcinoma group than in non-squamous cell carcinoma group.
作者
林翠波
林安
何海新
李玲
LIN Cui-Bo LIN An HE Hai-xin LI Ling(Department of Gynaecology, Fujian Tumor Hospital, Fuzhou 350014, China)
出处
《中国肿瘤临床与康复》
2017年第5期597-599,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
新辅助化疗
组织类型
局部晚期
Neoadjuvant chemotherapy
Tissue types
Locally advanced
