摘要
[目的]观察杞黄颗粒治疗肝肾阴虚型年龄相关性黄斑变性的临床疗效。[方法]肝肾阴虚型年龄相关性黄斑变性干性、湿性患者共120例,随机分为杞黄颗粒治疗组62例、维生素C对照组58例,观察治疗前后视力及中医证候评分变化。[结果]视力方面:对年龄相关性黄斑变性(AMD)患者治疗组与对照组治疗前后的总体视力进行组间比较,差异无统计学意义(P>0.05);对AMD患者治疗组与对照组治疗前后的总体视力进行组内比较,差异有统计学意义(P<0.05);杞黄颗粒治疗组显效24例,有效36例,无效2例,总有效率为96.77%。维生素C对照组显效4例,有效31例,无效23例,总有效率为60.35%。治疗组中医证候的改善明显优于对照组,经秩和检验,两组治疗前后对比差异有统计学意义(P<0.05)。杞黄颗粒治疗组内干性共45例,显效19例,有效24例,无效2例,总有效率为95.56%;湿性共17例,显效5例,有效12例,无效0例,总有效率为100%。经秩和检验,干性与湿性对比结果差异无统计学意义(P>0.05)。[结论]杞黄颗粒和维生素C对肝肾阴虚型AMD患者的视力均有一定的改善作用;杞黄颗粒对AMD患者的中医证候改善作用明显,具有良好的临床疗效。
[Objective] To observe the clinical effects of Qihuang Particles in liver-kidney deficiency of age-related macular degeneration （ AMD）. [Methods] All dates were processed by rank sum test, by adopting a pre- and post-treatment pairing study, a total of 120 patients with dry and wet liver-kidney deficiency AMD were randomly divided into Qihuang Particles treatment group （62 cases） and VC control group （58 cases） in order to investigate score changes of vision and TCM syndrome. [ Results] On the observe of vision： the differences of the overall vision between before and after treatment of the two groups are no statistically significant（P〉0.05）. But there are significant differences of the overall vision in the same group before and after contrast （P 〈0.05）. On the observe of TCM syndrome： 24 patients show an excellent effect in the Qihuang Particles treatment group, accounting for 38.71%; 36 of effective, accounting for 58.06%, and 2 of ineffective, accounting for 3.23%, with an overall response rate （ ORR） of 96.77%. Four patients show an excellent effect in the VC control group, accounting for 6.90%; 3 1 of effective, accounting for 53.45%; and 23 of ineffective, accounting for 38.65%, with an ORR of 60.35%. The improvement of TCM syndrome in the treatment group is significantly superior to control group. The difference has statistical significance （ P〈0.05） compared to pre- and post-treatment between two groups via rank-sum test. Among 45 patients with dry type in the Qihuang Particles treatment group, 19 patients show an excellent effect, accounting for 42.22%; 24 of effective, accounting for 53.33%; 2 of ineffective, accounting for 4.44%, with an ORR of 95.56% while among 17 patients with wet type, 5 patients show an excellent effect, accounting for 29.41%; 12 of effective, accounting for 70.59%; 0 of ineffective, accounting for 0%, with an ORR of 100%. The difference has no statistical significance （ P〉 0.05） compared to dry and wet type of patients via rank-sum test. [ Conclusion] Qihuang granule and vitamin C on liver-kidney yin deficiency type of age-related macular degeneration patiengts of vision have a certain improving effect. Qihuang Particles can significantly improve the TCM syndrome in patients with AMD with an excellent clinical effect.
作者
张欣桐
梁凤鸣
王莉
王燕
黎红梅
孟梁
ZHANG Xin- tong LIANG Feng-ming WANG Li WANG Yan LI Hong-mei MENG Liang(l.Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China First Teaching Hospital of Tianjin University ofTraditional Chinese Medicine, Tianjin 300193, China Guangdong Province Traditional Chinese Medical Hospital, Guangzhou, 510000, China)
出处
《天津中医药大学学报》
CAS
2017年第3期187-190,共4页
Journal of Tianjin University of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81373694)
关键词
年龄相关性黄斑变性
杞黄颗粒
中医证候
age-related macular degeneration （ AMD）
Qihuang Particles
TCM syndrome
