摘要
目的探讨老年维持性血液透析(MHD)患者使用左卡尼汀对营养状态的影响。方法选取2015年7月至2016年6月在顺德区第二人民医院行规律血液透析治疗的老年MHD患者88例,根据是否使用左卡尼汀干预分为观察组(45例)与对照组(43例)。比较两组患者治疗前后白蛋白(ALB)、前白蛋白(PA)、C反应蛋白(CRP)、转铁蛋白(TF)、总胆固醇水平(TC)和营养状态,并记录治疗组治疗过程中的不良反应发生情况。结果治疗后,观察组患者体重明显高于对照组,差异有统计学意义(P<0.05);观察组患者治疗期间低血压、肌肉痉挛、食欲增加、呕吐、恶心发生率均显著低于对照组,差异均有统计学意义(均P<0.05);治疗后,观察组患者的ALB、PA、TRF以及SGA评分均明显高于对照组,CRP明显低于对照组,差异均有统计学意义(均P<0.05)。结论左卡尼汀能有效提高老年MHD患者的营养状况。
Objective To investigate the elderly maintenance hemodialysis （MHD） patients using the effects of L-carnitine on nutritional status.Methods From July 2015 to June 2016 in 88 cases in Shunde Second People＇s Hospital for hemodialysis treatment in elderly patients with MHD,depending on whether the use of L-carnitine intervention divided into observation group （45 cases） and control group （43 cases）.Two groups were compared before and after treatment of albumin （ALB）,prealbumin（PA）,C reactive protein （CRP）,transferrin （TF）,total cholesterol （TC） and nutritional status,and record the adverse reaction of treatment group in the process of occurrence.Results After treatment,patients in the observation group were significantly higher than the control group,the difference was statistically significant（P〈0.05）;patients in the observation group during the treatment of hypotension,muscle spasm,increased appetite,vomiting,nausea and vomiting were significantly lower than the control group,the differences were statistically significant（P〈0.05）;after treatment,ALB group of patients TRF, PA, and SGA scores were significantly higher than the control group,CRP was significantly lower than the control group,the differences were statistically significant（P〈0.05）.Conclueion L-carnitine can improve the nutritional status of elderly patients with MHD.
出处
《中国药物经济学》
2017年第5期79-81,共3页
China Journal of Pharmaceutical Economics
关键词
左卡尼汀
血液透析
营养状况
老年
L-carnitine
Hemodialysis
Nutritional Status
Gerontism
