摘要
目的比较艾司西酞普兰和氟西汀治疗首发抑郁症的疗效及认知功能影响。方法以我院84例首发抑郁症患者为观察对象,将其随机分成两组,每组42例,A组使用艾司西酞普兰治疗,B组使用氟西汀治疗,比较两组的疗效和认知功能。结果两组治疗后汉密尔顿抑郁量表(HAMD)评分均降低,组间HAMD评分比较,差异有统计学意义,P<0.05,A组治疗总有效率83.3%,B组治疗总有效率66.7%,组间比较,差异有统计学意义,P<0.05。两组威斯康星卡片测试认知功能结果比较,差异无统计学意义,P>0.05,两组用药期间未出现严重不良反应。结论艾司西酞普兰治疗首发抑郁症的疗效优于氟西汀,两种药物对认知功能的影响相差不大。
Objective To compare the efficacy and cognitive function of escitalopram and fluoxetine in the treatment of first-episode depression. Methods 84 cases of first-episode depression patients in our hospital were taken as the object of observation, they were randomly divided into two groups, 42 cases in each group, A group was treated with escitalopram, B group was treated with fluoxetine, the efficacy and cognitive function of the two groups were compared. Results The Hamilton depression scale （HAMD） score of two groups were decreased after treatment, between groups, the difference of HAMD score was statistically significant, P〈0.05, total effective rate in A group was 83.3%, total effective rate in B group was 66.7%, the difference was statistically significant, P〈0.05, the difference of Wisconsin card test cognitive function results between two groups was not statistically significant, P〉0.05, during the medication, there was no serious adverse reactions in the two groups. Conclusion Escitalopram is more effective than fluoxetine in the treatment of first-episode depression, and the two drugs have no significant effect on cognitive function.
出处
《中国继续医学教育》
2017年第12期198-199,共2页
China Continuing Medical Education
关键词
艾司西酞普兰
氟西汀
首发抑郁症
疗效
认知功能
escitalopram
fluoxetine
first-episode depression
efficacy
cognitive function
