摘要
目的分析第四军医大学第一附属医院内分泌代谢科药品不良反应(ADR)的发生特点,为临床合理用药提供科学依据。方法收集第四军医大学第一附属医院内分泌代谢科2013年1月—2016年4月上报的137例ADR报告,对患者的年龄和性别、药品种类、所涉及的器官及系统、临床表现等方面进行统计与分析。结果 137例ADR报告中,男性78例(56.93%),女性59例(43.07%);40~70岁患者最多,共计100例(72.99%);ADR涉及药物以二甲双胍最多(40.86%);ADR的临床表现以胃肠系统损害最常见,共计61例(44.52%)。结论第四军医大学第一附属医院内分泌代谢科发生的ADR有其自身特点,ADR的发生与多种因素有关,加强对ADR的监测工作,有利于促进临床合理用药和保障患者用药安全。
Objective To investigate the characteristics of adverse drug reactions （ADR） occurred in Department of Endocrinology and Metabolism of the First Hospital Affiliated to the Fourth Military Medical University, in order to provide scientific basis for clinical rational drug use. Methods ADR reports （137 cases） were selected from Department of Endocrinology and Metabolism of the First Hospital Affiliated to the Fourth Military Medical University from January 2013 to April 2016, and the age and gender of patients, drug categories, involved organs and systems, and clinical manifestations were analyzed. Results Among 137 cases of ADR, 78 cases were male （56.93%）, and 59 cases were female （43.07%）. Totally 100 cases of ADR occurred in the patients aged from 40 to 70 years old, accounting for 72.99% of the total number. In the ADR-involving drugs, the number of ADR caused by metformin （40.86%） was the most. Gastrointestinal reactions （61 cases） were the most common clinical manifestations, accounting for 44.52%. Conclusion ADR in the Department of Endocrinology and Metabolism of the First Hospital Affiliated to the Fourth Military Medical University has its own characteristics. The occurrence of ADR is related to multiple factors. Enhancing the ADR monitoring work is helpful to promote the clinical rational drug use and protect the medication safety.
出处
《现代药物与临床》
CAS
2017年第5期942-945,共4页
Drugs & Clinic
基金
西京医院学科主推转化医学项目(XJZT13Z04)
吴阶平医学基金会临床科研专项资助基金
关键词
药品不良反应
合理用药
二甲双胍
adverse drug reaction
rational drug use
metformin
