摘要
目的研究尿中百草枯(Paraquat,PQ)半定量试验对急性PQ中毒严重程度评估的意义。方法依据尿中PQ半定量试验结果,将186例PQ中毒病例分为+组(37例)、++组(25例)、+++组(27例)和++++组(97例),比较四组病例的临床特征、肝肾损害及呼吸衰竭的情况,用Kaplan-Meier法进行生存率分析。结果 186例PQ中毒患者死亡92例,病死率为49.46%。+组病例无严重并发症,++++组病例急性呼吸、肝肾衰竭发生率明显高于其他组,差异均有统计学意义(P<0.05)。尿中PQ浓度和肝、肾功能异常显著相关(r肾脏功能=0.756,r肝功能=0.574,P<0.001)。Kaplan-Meier生存分析显示,++++组病死率(78.35%)明显高于+++组(55.56%)、++组(4.0%)和+组(0%),差异有统计学意义(P<0.05)。结论尿PQ半定量试验可较好判断急性PQ中毒的严重程度,可对急性PQ中毒患者指导治疗,预测预后。
Objective To study the value of semi-quantification test of urine paraquat in evaluating the severity of patients with acute paraquat poisoning. Methods A total of 186 patients with acute paraquat poisoning were categorized into four groups according to their semi-quantification test results of urine paraquat： ＋ group（ n = 37）,＋ ＋group（ n = 25）,＋ ＋ ＋ group（ n = 27）, and ＋ ＋ ＋ ＋ group（ n = 97）. The clinical features, severity of hepatic and renal injuries and respiratory failure were compared among these four groups. Kaplan-Meier analysis was used to evaluate the survival rate. Results Totally 92 of the 186 patients with paraquat poisoning died, the mortality rate being49. 46%. No patient in ＋ group was found to have serious complications; the incidence of acute respiratory failure, renal failure, and hepatic failure in ＋ ＋ ＋ ＋ group was significantly higher than that of the other groups（ P 0. 05）. The urine paraquat concentration was positively correlated with the dysfunction of liver and kidney（ Spearman correlation coefficient,r= 0. 756 and 0. 574,P 0. 001）. Kaplan-Meier survival analysis showed that the mortality of ＋ ＋ ＋ ＋ group（ 78. 35%） was significantly higher than that of, the other groups（ P 0. 05）. Conclusion The semi-quantification test of urine paraquat is a promising test in evaluating the severity of acute paraquat poisoning. This test can be used to guide therapy and to predict the outcomes of patients suffering from acute paraquat poisoning.
出处
《实用药物与临床》
CAS
2017年第6期683-686,共4页
Practical Pharmacy and Clinical Remedies
关键词
百草枯
中毒
百草枯半定量试验
预后评价
Paraquat
Poisoning
Semi-quantification test of urine paraquat
Outcome evaluation
