摘要
目的 观察甘精胰岛素联合甲巯咪唑治疗老年糖尿病并发甲亢的效果.方法 对海盐县人民医院2014年5月-2016年5月收治的老年糖尿病并发甲亢患者80例的临床资料进行统计分析.结果 联合治疗组患者的空腹血糖、餐后2h血糖水平均显著低于单独治疗组（P〈0.05）,TSH水平显著高于单独治疗组（P〈0.05）,FT3、FT4、TGAb、TMAb水平均显著低于单独治疗组（P〈0.05）,治疗的总有效率85.0%（34/40）显著高于单独治疗组40.0%（16/40）（P〈0.05）,胰岛素用量显著少于单独治疗组（P〈0.05）,血糖达标时间、住院时间均显著短于单独治疗组（P〈0.05）,不良反应发生率12.5%（5/40）显著低于单独治疗组47.5%（19/40）（P〈0.05）.结论 甘精胰岛素联合甲巯咪唑治疗老年糖尿病并发甲亢的效果较甘精胰岛素单独治疗好.
Objective To observe the effect of insulin glargine combined with methimazole treatment of senile diabetes mellitus complicated with hyperthyroidism.MethodsThe clinical data of 80 cases in People＆#39;s Hospital of Haiyan from May 2014 to May 2016 were elderly diabetic patients with hyperthyroidism were analyzed.ResultsThe combined treatment group of patients with fasting blood glucose, 2h postprandial blood glucose was significantly lower than the average water alone treatment group （P〈0.05）, TSH level was significantly higher than that of single treatment group （P〈0.05）, FT3, FT4, TGAb, TMAb levels were significantly lower than the single treatment group （P〈0.05）, the total efficiency of 85% treatment （34/40） was significantly higher than that of single the treatment group of 40% （16/40） （P〈0.05）, insulin was significantly less than single treatment group （P〈0.05）, blood glucose time, hospitalization time were significantly shorter than single treatment group （P〈0.05）, the incidence of adverse reactions was 12.5% （5/40） was significantly lower than that of single treatment group 47.5% （19/40） （P〈0.05）.ConclusionInsulin glargine combined with methimazole in treatment of elderly diabetes mellitus complicated with hyperthyroidism was better than insulin glargine treatment alone.
作者
张美琴
吴海锋
庞晓琴
ZHANG Mei-qin WU Hai-feng PANG Xiao-qin(Department of Endocrinology, People＇s Hospital of Haiyan, Jiaxing 314300, China)
出处
《中国生化药物杂志》
CAS
2017年第6期53-55,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
甘精胰岛素
甲巯咪唑
老年糖尿病
甲亢
效果
insulin glargine
methimazole
elderly diabetes mellitus
hyperthyroidism
effect
