摘要
【目的】探讨血清丝氨酸蛋白酶抑制剂（Vaspin）、肿瘤坏死因子相关蛋白9（CTRP9）在多囊卵巢综合征（PCOS）患者中的表达及其意义。【方法】收集2015年3月至2016年8月在本院确诊为PCOS患者59例（观察组），按照WHO肥胖标准[体质量指数（BMI）≥25kg／m2]分为非肥胖28例（观察A组）、肥胖31例（观察B组）；另选同期在本院行体检的健康女性60例（对照组），根据BMI分为非肥胖31例（对照A组）、肥胖29例（对照B组）。检测并比较四组受栓者血清中Vaspin、CTRP9水平，比较四组一般情况及生化指标如三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、空腹胰岛素（FINS）、总睾酮、胰岛素抵抗指数（HOMA-IR）及稳态期120-180min葡萄糖代谢率（M120-180）。【结果】观察组血清Vaspin水平明显高于对照组，血清CTRP9水平明显低于对照组，其差异有统计学意义（P〈0．05）；Pearson相关分析显示，Vaspin水平与患者HDL-C、M120-180呈负相关（P〈0．05），与BMI、TC、LDL-C、腰围、FINS、TG、总睾酮、HO-MA-IR水平呈正相关（P〈0．05）；CTRP9水平与患者HDL-C、M120-180呈正相关（P〈0．05），与BMI、TC、LDL-C、腰围、FINS、TG、总睾酮及HOMA-IR水平呈负相关（P〈0．05）；血清Vaspin、CTRP9水平与年龄均无明显相关性（P〉0．05）。【结论】与健康人群相比，PCOS患者血清Vaspin水平较高，CTRP9水平低；BMI、TC、HDL-C、腰围、FINS、TG、总睾酮、HOMA-IR、LDL-C、M120-180指标与血清Vaspin、CTRP9水平密切相关。
[Objective]To investigate the expression and significance of serum Vaspin and CTRP9 levels in patients with polycystic ovary syndrome. [Methods] Fifty-nine cases diagnosed PCOS patients from March 2015 to August 2016 in our hospital （observation group） were selected, according to the body mass index [（BMI） WHO obese than 25kg/m2] they wee divided into non obese group A （28 cases）, obesity group B （31 cases ） ; In addition, 60 healthy women （con- trol group） who underwent physical examination in our hospital were divided into non obese 31 cases （control group A） and obesity 29 cases （control group B） according to BMI. Detection and comparison of four groups of patients with serum Vaspin, CTRP9 levels were compared between the four groups in general and biochemical indicators such as three triglyc- erides （TG）, total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, fasting insulin resistance index （FINS）, total testosterone and insulin （HOMA-IR）, and the level of steady period of 120 to 180 rain glucose metabolic rate （M120-180）.[Results] The serum Vaspin level of the observation group was significantly higher than that of the control group, and the serum CTRP9 level was significantly lower than that of the control group, the difference was statistically significant （ P 〈0.05）; Pearson correlation analysis showed that the level of Vaspin was negatively correlated with HDL-C and M120-180 （ P 〈0.05）, and positively correlated with BMI, TC, LDL-C, waist circumference, FINS, TG, total testosterone, and HOMA-IR levels （P 〈0.05）; The level of CTRP9 was positively correlated with HDLC and M120-180 （ P〈0.05）, and negatively correlated with BMI, TC, LDL-C, waist circumference, FINS, TG, total testosterone and HOMA-IR levels （ P 〈0.05） ; Serum levels of Vaspin and CTRP9 were not significantly correlated with age （ P 〉0.05）. [Conclusion] Compared with the healthy population, PCOS patients have higher serum Vaspin levels and lower CTRP9 levels; The indexes of BMI, TC, HDL-C, waist circ- umference, FINS, TG, total testosterone, HOMA-IR, LDL-C and M120-180 were closely related to serum levels of Vaspin and CTRP9.
出处
《医学临床研究》
CAS
2017年第6期1081-1083,1086,共4页
Journal of Clinical Research
