摘要
目的:研究当归四逆汤对系统性硬化病(SSc)患者ANA及Scl-70的影响。方法:将系统性硬化病患者60例随机分为当归四逆汤组(中药组)、D-青霉胺组(西药组)和当归四逆汤加D-青霉胺组(中西医结合组),每组各20例,服药2个月后,观察患者抗核抗体(ANA)、抗Scl-70抗体的变化。结果:3组受试者治疗3个月后,患者ANA、抗Scl-70抗体均有不同程度的变化。ANA:治疗前后各组组内对照、中药组及中西医结合与西药组对比,差异均具有统计学意义(P<0.05),中药组与中西医结合组对比,差异无统计学意义(P>0.05)。抗Scl-70抗体:治疗前后各组组内对照、中药组及中西医结合组与西药组对照、中药组与中西医结合组对照,差异均具有统计学意义(P<0.05)。结论:对SSc患者ANA及抗Scl-70抗体治疗效果而言,当归四逆汤对SSc的治疗作用比D-青霉胺更具优势,二者结合使用效果更佳。
Objective： To study the effect of Danggui Sini Decoction on ANA and Scl-70 in patients with systemic sclerosis （SSc）. Methods： The patients with systemic sclerosis were randomly divided into 60 eases of Danggui Sini Decoction group （Chinese Medicine group）, D- penicillamine group （Western medicine group） and Danggui Sini Decoction and Tonga D-penicillamine group（WM group）, 20 eases in each. The antinuclear antibody（ANA） and the changes of anti Sel-70 antibodie were observed intwo months. Result： The anti SeL-70 antibody showed varying degrees of change in the three groups in three months. ANA： before and after treatment in each group, the Chinese Medicine group and WM group compared with western medicine group, the differences were statistically significant （P〈0.05）; Chinese medicine group and Western medicine group comparison was not statistically significant （P〉0.05）. Anti SOL-70 antibody： before and after treatment in each group, the Chinese Medicine group, WM group and Western medicine group, Chinese medicine group and the WM group, the difference was statistically significant （P〈0.05）. Conclusion： Danggui Sini Decoction showed better efficacy than D- penieillamine on ANA and anti Scl-70 antibody in SSe patients, and the combined application showed better effect.
作者
朴勇洙
于洋洋
PIAO Yong-zhu YU Yang-yang(The First Aftiliated Hospital of Heilongiiang University of Chinese Medicine, Harbin Heilongiiang 150040, China Heilongiiang University of Chinese Medicine, Harbin Heilongfiang 150040, China)
出处
《中医药导报》
2017年第13期93-95,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
教育部"春晖计划"项目(z2010041)
