摘要
TLR4信号通路参与调节固有免疫反应与适应性免疫反应,其与抑郁症免疫炎症过程关系密切,但其具体机制尚不十分明确。抑郁症的病理生理过程包括了多种分子机制和信号通路,抑郁症患者及抑郁动物模型的外周循环系统或中枢神经系统均存在TLR4信号通路的变化。体内TLR4信号通路的激活与"应激-炎症-抑郁"途径以及"肠漏"假说密切相关,然而目前外周与中枢TLR4信号通路的关系尚未明确。TLR4信号通路可能为抑郁症抗炎治疗的潜在靶点。
TLR4 signaling pathway plays an important role in regulation of the innate immune response and the adaptive immune response.Studies have shown that TLR4 signaling pathway is closely associated with the immune inflammatory process in major depressive disorder,but the underlying mechanisms are not clear.The pathophysiological process of depression involves multiple molecule mechanisms and signal pathways.The change of TLR4 signaling pathways exists in the peripheral circulation system or the central nervous system of depressive patients and depression animal models.The activation of TLR4 signaling pathways is associated with ＂stress-inflammationdepression＂ approach and ＂leaky gut＂ hypothesis,however,the relationship of peripheral and central TLR4 signaling pathways is not clear yet.TLR4 signaling pathway may be potential targets for the anti-inflammatory treatment of depression.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2017年第6期725-729,共5页
Journal of Central South University ：Medical Science
关键词
TLR4信号通路
抑郁症
应激
肠漏
TLR4 signaling pathways
major depressive disorder
stress
leaky gut
