摘要
目的:探讨黄芪对儿童肾病综合征高血脂症ADPN及LP水平的影响。方法:选取符合纳入标准的120例肾病综合征高血脂症患儿按照随机数字表法分为对照组和对照组,每组60例,两组患儿均进行常规激素治疗,治疗组在此基础上给予黄芪注射液,治疗2个疗程。分别于治疗前后检测并比较两组患儿的血脂指标、脂联素以及瘦素和相关指标。结果:治疗后治疗组疗效显著高于对照组(P<0.05),两组的Alb水平均显著升高,而BUN、Scr、血和尿β_2-MG、尿NAG和24 h尿蛋白定量等指标均显著降低,且治疗组的变化幅度显著高于对照组(P<0.05);治疗后两组患儿除HDL水平显著升高外(P<0.05),其他血脂指标均显著降低(P<0.05),且治疗组的变化幅度显著高于对照组(P<0.05),治疗后两组患儿血清ADPN含量及FLI水平均明显降低(P<0.05),sOBR水平明显升高(P<0.05),且治疗组的变化幅度显著高于对照组(P<0.05),而Leptin水平均没有显著变化(P>0.05)。结论:黄芪对儿童PNS高血脂症疗效显著,能降低血液中脂联素和瘦素水平,可以作为儿童PNS治疗的常规辅助用药。
Objective：To analyze the effect of Astragalus on adiponeetin（ADPN） and leptin （LP） in hyperlipidemia children with nephrotie syndrome （NS）. Methods ：120 NS children were randomly divided into the control group and the observation group, with 60 eases in each group. Both groups were treated with conventional hormone therapy, and the treatment group was also given Astragalus（Huangqi） injection. Blood lipid indexes, and the levels of ADPN and LP were detected and compared before treatment and after treatment in both groups. Results：After treatment, the clinical effect of the observation group was significantly higher than that of the control group （P 〈 0.05） ; the levels of Alb were significantly inereased, while BUN, Ser, β2 - MG in blood and urine, urinary NAG and 24 h urinary protein were significantly decreased in both groups, and there were significant differences between the two groups （ P 〈 0.05 ） ; the content of HDL were significantly in- creased（P 〈0.05）, other lipids were significantly reduced（P 〈0.05） in both groups, and the changes in the treatment group were significantly more than those in the control group （P 〈 0.05） ; the content of ADPN and FLI were significantly decreased （P 〈 0.05 ）, and the level of sOBR was significantly increased （ P 〈 0.05 ） in both groups, and the variation amplitude of the observation group was significantly higher than that of the control group （P 〈 0.05 ） ; however, there was no difference between before and after treatment （ P 〉 0.05 ）. Conclusion ： Astragalus has a the two groups in terms of leptin both significant effect on hyperlipidemia in PNS children. It can reduce the levels of ADPN and LP in the blood, which can be used as a routine assistant medication for PNS.
作者
张川琳
江念
张春娇
ZHANG Chuan- Lin JIANG Nian ZHANG Chun-Jiao(Wuhan Children＇s Welfare Institute, Wuhan 430060, Chin)
出处
《中医药信息》
2017年第4期63-67,共5页
Information on Traditional Chinese Medicine
