摘要
目的分析血浆氨基末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)浓度与急性心力衰竭(心衰)患者心功能分级的相关性。方法前瞻性选择新疆医科大学第二附属医院78例住院急性心衰患者,依据出院后随访1年心功能分级分为两组:轻度组36例,纽约心脏协会(New York Heart Association,NYHA)心功能分级1级与2级;重度组42例,心功能NYHA分级3级与4级。比较住院期间两组患者NT-proBNP浓度及心指数(cardiac index,CI)、左心室舒张末期内径(left ventricular end diastolic dimension,LVEDd)、左心室射血分数(left ventricular ejection fraction,LVEF)的差异。应用Pearson相关分析评估NT-proBNP浓度与心功能NYHA分级的相关性,利用多元Logistic回归分析与急性心衰患者心衰加重的危险因素。结果与轻度组相比,重度组血浆NT-proBNP浓度显著较高,差异有统计学意义(P<0.05);两组CI、LVEF及LVEDd比较,差异无统计学意义(P>0.05)。Pearson相关分析显示,NT-proBNP浓度与随访心功能NYHA分级呈正相关(P<0.05),而CI、LVEF及LVEDd与随访心功能NYHA分级无相关性(P>0.05)。多元Logistic回归分析显示,血浆NT-proBNP浓度为急性心衰患者心衰加重的危险因素。结论急性心衰患者血浆NT-proBNP浓度能较好评估其心功能分级情况。
Objectives To analyze the correlation of plasma concentration of N-terminal pro-brain natriuretic peptide（NT-proBNP）and cardiac function grade in patients with acute heart failure（AHF）. Methods The 78 patients withAHF were collected to prospective study and divided into two groups according to the cardiac function grade after oneyear follow-up,which were mild group[36 cases,the New York Heart Association（NYHA）grade was 1 or 2]andsevere group（42 cases,the NYHA grade was 3 or 4）. Plasma concentration of NT-proBNP,cardiac index（CI）,leftventricular end diastolic diameter（LVEDd）,left ventricular ejection fraction（LVEF）were compared between the twogroups. Correlations of plasma concentration of NT-proBNP and NYHA grade were evaluated by Pearson correlationanalysis. Risk factors of serious heart failure in patients with AHF were confirmed by multivariate Logistic analysis.Results Compared with mild group,plasma concentration of NT-proBNP in severe group was higher（P〈0.05）,butCI,LVEF and LVEDd were not different between the two groups（P〉0.05）. Positive correlations of plasmaconcentration of NT-proBNP and NYHA grade after one year follow-up was confirmed by Pearson correlationanalysis,and there were no correlations of NYHA grade with CI,LVEF and LVEDd. Multivariant Logistic analysisshowed that plasma concentration of NT-proBNP was an independent risk factor to the serious heart failure in patientswith AHF. Conclusions Plasma concentration of NT-proBNP could assess the degree of cardiac function grade inpatients with AHF.
作者
阿不来提.海里力
张红玉
文进
ABuLaiti-HaiLi Ge ZHANG Hong-Yu WEN-Jin(Department of Intensive Care Unite, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830017, China)
出处
《岭南心血管病杂志》
2017年第3期294-297,共4页
South China Journal of Cardiovascular Diseases
基金
新疆医科大学科研创新基金(项目编号:XYDCX201534)
关键词
心力衰竭
氨基末端脑钠肽前体
纽约心脏协会心功能分级
相关分析
heart failure
N-terminal pro-brain natriuretic peptide
New York Heart Association grade
correlation analysis
