摘要
RNF180是一种新型的膜结合E3泛素连接酶,参与了细胞的发育、增殖及细胞凋亡,是一种抑癌基因,具有抑制细胞增殖和诱导凋亡的作用,也可能与胃癌的淋巴转移相关.研究发现,RNF180基因甲基化与胃癌的发生及发展密切相关,RNF180基因甲基化有望作为胃癌的肿瘤标志物用于胃癌的早期诊断及预后评估.
RNF180 is a novel membrane-bound E3 ubiquitin ligase that participates in cell development,proliferation and apoptosis.It is a tumor suppressor gene that inhibits cell proliferation and induces apoptosis and may inhibit gastric cancer cell lymph node metastasis.The study found that RNF180 gene methylation and gastric cancer is closely related to the occurrence and development.Therefore,RNF180 gene methylation is expected as a tumor marker of gastric cancer for early diagnosis and prognosis of gastric cancer.In this paper,RNF180 on the diagnosis of gastric cancer research progress made a review.
出处
《中国综合临床》
2017年第6期565-568,共4页
Clinical Medicine of China
关键词
RNF180
甲基化
胃癌
预后
淋巴转移
RNF180 Methylation
Gastric cancer
Prognosis
Lymph node metastases
