摘要
目的:调查我院儿科住院患者超药品说明书用药情况,并进行分析评价,为儿科患者的规范合理用药提供参考。方法:采用回顾性调查,随机抽取2016年2月1日到3月31日住院患儿病例600例,逐一阅读药品包装所附药品说明书,判断超药品说明书用药处方并分析其原因。结果:共纳入住院病例600例,分析用药医嘱3 769条,涉及药品157种。按病例数、用药医嘱、药物品种计,超药品说明书用药分别为93.2%、31.8%和30.6%。各类型超药品说明书用药发生率分别为超适用人群(66.0%)、超适应证(25.6%)、超给药途径(22.6%)、超给药剂量(11.1%);超药品说明书用药医嘱占据第一位的药物为心血管系统药(26.5%),其次为呼吸系统类药物(21.6%)。结论:儿科住院患者超药品说明书用药现象普遍,相关管理部门应对超药品说明书用药行为进行规范,保障患儿用药安全,规避用药风险。
Objective：To research the actuality of off-label drug use on pediatric inpatients in a certain hospital, and to analyze and comment on these cases to provide a reference for rational drug use and standard medication on children clinically. Methods： With the method of retrospective investigation, 600 hospitalized cases of pediatrics from February 1,2016 to March 31,2016 were selected at ran- dom. To read the package inserts of drug one by one. Then the prescriptions which are off-label use were screened out and analyzed their reasons. Results： A total of 600 hospitalized children were included, and 3769 medical orders were analyzed, involving 157 typed. By the number of prescriptions,medication records and drug types,the incidence of off-label drug use were 93.2% , 31.8% and 30. 6%. The type of off-label drug use mainly included off-label suitable crowd（66. 0% ）, off-label indication （25.6%） ,exceeding route of administra- tion （22. 6% ）, off-label dosage （11.1% ）. The top-one drugs in the list of the incidence of off-label drug use were drugs for cardiovascular drugs （26. 5% ）, the second were drugs for respiratory system （21.6%）. Conclusion： The phenomenon of off-label drug use on pediatric inpatient is pervasive in the hospital. Relevant administrative departments should formulate the management system of off-label drug use which is supposed to be standardized reasonably, in order to guarantee safe medications for children, and to avoid drug risks.
出处
《中国药物评价》
2017年第3期231-233,共3页
Chinese Journal of Drug Evaluation
关键词
超药品说明书用药
儿科患者
处方分析
调查
合理用药
Off-label drug use
Pediatric inpatients
Prescription analysis
Research
Rational use of drug
