摘要
目的研究分析来曲唑联合克罗米芬对多囊卵巢综合征妇女促排卵及生殖激素变化的影响。方法选取镇海区人民医院2015年1月~2016年12月收治的100例多囊卵巢综合征妇女作为本研究的研究对象,随机分为对照组和试验组2组,每组50例。对照组患者予以克罗米芬治疗,试验组患者予以来曲唑与克罗米芬治疗。比较分析试验组患者的生殖激素水平以及排卵率和妊娠率。结果试验组患者的排卵率为90.0%,妊娠率46.0%,卵泡数量为（1.2±0.4）个。对照组患者排卵率为72.0%,妊娠率22.0%,卵泡数量为（2.2±0.5）个。试验组患者排卵率与妊娠率显著高于对照组患者,差异具有统计学意义（P〈0.05）。对照组患者卵泡数量显著多于对照组,差异具有统计学意义（P〈0.05）。试验组与对照组患者卵泡成熟时间的差异无统计学意义,试验组患者生殖激素水平显著低于对照组,差异具有统计学意义（P〈0.05）。结论来曲唑与克罗米芬治疗多囊卵巢综合征,可提高患者的排卵率和妊娠率,有效降低患者生殖激素水平,具有临床应用价值。
Objective To study the effects of letrozole and clomiphene on the treatment of ovulation induction and the changes of reproductive hormone in the patients with polycystic ovary syndrome. Methods In Zhenhai District People＇s Hospital from January 2015 to December 2016,100 cases with polycystic ovary syndrome as the research object in this study,were randomly divided into the control group and the experimental group,50 cases in each group. The control group were treated with clomiphene,the experimental group were given letrozole combined clomiphene. The levels of reproductive hormones,ovulation rate and pregnancy rate were compared in the two groups. Results The ovulation rate was 90%,pregnancy rate was 46%,the numbers of follicles was（ 1. 2 ± 0. 4）. In the control group,the ovulation rate was 72%,the pregnancy rate was 22%,and the number of follicles was（ 2. 2 ± 0. 5）. The results showed that the ovulation rate and pregnancy rate in the experimental group were significantly higher than those in the control group,with statistical significance（ P 〈0. 05）. The number of follicles in the control group was significantly higher than that in the control group,with statistical significance（ P〈 0. 05）. There was no significant difference between the experimental group and the control group in the time of follicular maturation,which was not statistically significant. The levels of reproductive hormones in the experimental group were significantly lower than those in the control group,with statistical significance（ P 〈0. 05）. Conclusion Letrozole combined clomiphene can improve the ovulation rate and pregnancy rate,reduce the reproductive hormone level,which has clinical application value.
出处
《中国生化药物杂志》
CAS
2017年第7期257-258,共2页
Chinese Journal of Biochemical Pharmaceutics
关键词
来曲唑
克罗米芬
多囊卵巢综合征
促排卵
生殖激素
letrozole
clomiphene
polycystic ovary syndrome
ovulation induction
reproductive hormone
