七氟醚预处理对单肺通气过程中肺泡氧合功能及全身炎症反应激活的影响被引量：5

Effect of sevoflurane pretreatment on alveolar oxygenation function and systemic inflammatory response during one-lung ventilation

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摘要目的:研究单肺通气前进行七氟醚预处理对肺顺应性、氧合功能及全身炎症反应程度的影响。方法:选择2014年4月~2015年12月期间在绵阳市中心医院接受单肺通气手术的104例患者,随机分为接受七氟醚预处理联合常规麻醉的七氟醚组和接受常规麻醉的对照组,检测单肺通气过程中的肺顺应性、氧合功能参数以及血清中炎症介质的含量、肺灌洗液中炎症调节分子的含量。结果:单肺通气后30min(T1)、单肺通气后60 min(T2)、恢复双肺通气后20 min(T3)时,七氟醚组患者肺顺应性Cdyn、氧合指数PaO_2/FiO_2的水平均显著高于对照组,血清中细胞间黏附分子(ICAM)-1、白介素(IL)-6、IL-8、肿瘤坏死因子(TNF)-α的含量均显著低于对照组,IL-10的含量显著高于对照组;手术结束后,七氟醚组患者萎陷侧肺灌洗液中AQP-1、p38MAPK、TLR4、NF-kB的含量均显著低于对照组。结论:单肺通气前进行七氟醚预处理能够改善肺顺应性和氧合功能、抑制炎症反应的激活。 Objective：To study the effect of sevoflurane pretreatment before one-lung ventilation ventilation on pulmonary compliance,oxygenation function and systemic inflammatory response.Methods：A total of 104 patients who accepted one-lung ventilation operation in Mianyang Central Hospital between April 2014 and December 2015 were selected and randomly divided into the sevoflurane group who accepted sevoflurane pretreatment combined with routine anesthesia and the control group who accepted routine anesthesia,and the pulmonary compliance and oxygenation function parameters during one-lung ventilation as well as the contents of serum inflammatory mediators and the contents of inflammation regulation molecules in alveolar lavage fluid were determined.Results：At T1,T2 and T3,Cdyn and PaO2/FiO2 levels of sevoflurane group were significantly higher than those of control group,and serum ICAM-1,IL-6,IL-8and TNF-αcontents were significantly lower than those of control group while IL-10 contents were significantly higher than those of control group;after operation,AQP-1,p38 MAPK,TLR4and NF-kB contents in collapsed alveolar lavage fluid of sevoflurane group were significantly lower than those of control group.Conclusions：Sevoflurane pretreatment before one-lung ventilation can improve the pulmonary compliance and oxygenation function,and inhibit the activation of inflammatory response.

作者谢燕斌陈平陈怡霏陈龙平

机构地区绵阳市中心医院麻醉科

出处《海南医学院学报》 CAS 2017年第11期1502-1505,共4页 Journal of Hainan Medical University

基金四川省卫生厅课题(150077)~~

关键词单肺通气七氟醚预处理顺应性氧合功能炎症反应 One-lung ventilation Sevoflurane pretreatment Compliance Oxygenation function Inflammatory response

分类号 R655.3 [医药卫生—外科学]

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1陶洪霞,沈启英,李元海.七氟醚预处理对单肺通气时肺顺应性和氧合指数的影响[J].安徽医科大学学报,2016,51(5):682-685. 被引量：22

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