摘要
目的探讨凝血酶原时间和C反应蛋白联合检测对早期儿童脓毒症的诊断价值。方法 2015年3月至2016年5月湖南省儿童医院急诊综合内科收治的脓毒症患儿30例,为观察组。同期选取普通发热患儿30例为对照组。分别检测和记录两组患儿发病24h内外周静脉血的凝血酶原时间和C反应蛋白浓度,并对早期脓毒症的诊断准确度进行比较。结果观察组凝血酶原时间和C反应蛋白高于对照组,差异有统计学意义(P<0.05)。凝血酶原时间和C反应蛋白联合检测较单独检测两种指标中任一指标的特异性明显增高,假阳性降低,灵敏性亦有所降低。结论凝血酶原时间和C反应蛋白联合检测可以提高早期儿童脓毒症诊断的特异性,降低诊断的假阳性,有助于用于临床中对该病的早期诊断。
Objective To investigate the diagnostic value of determination of prothrombin time（PT） and C-reactive protein（CRP） in early childhood bacterial sepsis. Methods From March 2015 to May 2016 〉 30 children with bacterial sepsis and 30 children with common fever were treated in Hunan Childrens Hospi-tal, and they were assigned to study group and control group respectively. The prothrombin time and C-re-active protein （CRP） concentration in peripheral blood of the two groups were detected and recorded 24 hours after onset, and the accuracy of diagnosis was compared. Results The prothrombin time and C-reac-tive protein in the study group were significantly higher than those in the control group（P〈0. 05）. The combined determination of prothrombin time and C-reactive protein was more specific than either of the two indexes. The false-positive rate and specificity were decreased. Conclusion The combined detection of pro-thrombin time and C-reactive protein can improve the diagnosis specificity of early bacterial septicemia in children and reduce the false positive rate of diagnosis. It is helpful in the early diagnosis of the disease.
出处
《中国中西医结合儿科学》
2017年第4期324-326,共3页
Chinese Pediatrics of Integrated Traditional and Western Medicine
