摘要
目的探讨利福喷丁联合左氧氟沙星对复治肺结核病患者化疗的效果。方法采用随机的分配方式将86例初治失败转复治或复发肺结核病患者平分为两组,每组43例。治疗组强化期予左氧氟沙星联合利福喷丁、异烟肼、吡嗪酰胺、盐酸乙胺丁醇(3HRd ZEL/6HRd L)治疗,对照组强化期予左氧氟沙星联合利福平、异烟肼、吡嗪酰胺、盐酸乙胺丁醇(3HRZEL/6HRL)治疗,继续期两组患者均停用吡嗪酰胺、盐酸乙胺丁醇。通过治疗2个月末及疗程结束后的痰涂片阴转率、疗程结束后痰培养阳性率、肺部病灶吸收情况及空洞闭合率的比较,而得出两组患者治疗效果的差异。结果经正规抗结核方案治疗9个月,即疗程结束后,两组共有12例患者发生药物不良反应,其中3例因反应较重退出实验,另9例经积极处理后坚持完成疗程。按各项辅助检查进行比较分析。治疗组2个月末及疗程结束后的痰涂片阴性率均较对照组高。疗程结束后,对照组改良罗氏培养基痰培养结果阳性率较治疗组高。疗程结束后,治疗组在病灶总吸收率及空洞闭合率方面均较对照组高,差异有统计学意义。结论含左氧氟沙星联合利福喷丁抗结核化疗方案在复治肺结核病治疗中,更加有助于痰涂片阴转、病灶吸收及空洞闭合,能够提高治愈率。
Objective To compare the effect of levofloxacin combined with levofloxacin on chemotherapy in patients with retreated tuberculosis. Methods A total of 86 patients with initial treatment failure and turning to re-treatment or recurrent pulmonary tuberculosis were divided into two groups by random matching, with 43 cases in each group. The treatment group received levofloxacin combined with rifapentine, isoniazid, pyrazinamide, ethambuto] hydrochloride （3HRdZEL/6HRdL）therapy during intensive phase. The control group was treated with levofloxacin combined with ri- fampiein, isoniazid, pyrazinamide and ethambutol hydroehloride （3HRZEL/6HRL） therapy during intensive phase. Two groups of patients discontinued pyrazinamide and ethambutol hydrochloride in continuation phase. The difference of the curative effect between the two groups was obtained by comparing the negative rate of sputum smear after two months of treatment and the completion of treatment course, the positive rate of sputum culture, the absorption of lung lesions and the rate of empty closure after the completion of treatment course. Results After 9-month course of regular anti-tu berculosis treatment, the auxiliary examinations between the two groups were comparatively analyzed. A total of 12 cases of adverse drug reactions occurred in the two groups, 3 cases exited the experiment due to heavy reaction, and the other 9 eases adhered to complete the course of treatment after active treatment. After two months of treatment and the com- pletion of treatment course, the negative rate of sputum smear was higher in the treatment group than that of the control group. At the end of the treatment course, the positive rate of sputum culture results of modified Roche culture in the control group was significantly higher than that in the control group. After the completion of the treatment course, the treatment group was higher than the control group in both the total absorption rate of lesion and the closure rate of empty cavity, and there was significant difference. Conclusion Levofloxacin combined with rifapentine anti-tuberculo- sis chemotherapy regimen in the treatment of tuberculosis, is more conducive to sputum smear conversion, lesion ab- sorption and the closure of empty cavity, and can improve the cure rate.
出处
《中国现代医生》
2017年第23期80-83,共4页
China Modern Doctor
