摘要
目的探究右美托咪定对老年高血压患者全麻拔管期应激反应及苏醒时间的影响,为今后临床治疗提供可靠的经验。方法随机选取80例于2015年11月—2016年11月来该院就诊的行择期手术的Ⅰ~Ⅱ期原发性高血压患者将所有患者按照治疗方式不同分为两组观察组和对照组,每组40例。给予观察组患者0.5μg/kg右美托咪定,泵注时间为15 min。给予对照组患者0.5μg/kg氯化钠溶液。观察两组患者用药前(T0)、拔管前即刻(T1)、拔管后即刻(T2)、心率(HR)、肾上腺素(E)、去甲肾上腺素(NE)浓度的变化。结果两组患者在T0、T1、T2的HR、MAP、SpO_2的指标情况有明显变化,但在用药后观察组的指标变化显著于对照组(P<0.05),观察组和对照组患者的苏醒时间为(11.00±2.36)min和(9.00±2.20)min,清醒拔管时间为(15.36±3.45)min和(13.24±2.82)min,差异有统计学意义(P<0.05),表明右美托咪定对呼吸系统无明显抑制作用。结论右美托咪定有效减轻老年高血压患者在全麻拔管期的应激反应,保持相对稳定的血流动力学,不延迟苏醒时间及拔管时间,提高了手术的安全性。
Objective To study the effect of effect of dexmedetomidine on the stress and awakening time of senile pa- tients with hypertension during the general anesthesia tube drawing period and provide reliable experience for the fur- ther clinical treatment. Methods 80 cases of patients with primary hypertension for the selective operation during the Ⅰ and Ⅱ periods in our hospital from November 2015 to November 2016 were randomly divided into two groups with 40 cases in each according to the different treatment methods, the observation group were given the 0.5 μg/kg dexmedetomidine, and the pumping time was 15 min, and the control group were given the 0.5 μg/kg sodium chloride solution, and the changes of T0, T1, T2, HR, E and NE of the two groups were observed. Results There were obvious changes in the indexes of HR, MAP, SpO2 at T0, T1, T2, but after medication, the index changes in the observation group were obviously higher than those in the control group （P〈0.05）, and the differences in the awakening time and sober tube drawing time between the observation group and the control group were obvious, [（11.00±2.36）rain,（15.36± 3.45） rain vs（ 9.00±2.20）min, （13.24±2.82） min]（P〈0.05）, which showed that dexmedetomidine had no obvious inhibition effect on the respiration system. Conclusion Dexmedetomidine can effectively reduce the stress of senile patients with hypertension during the general anesthesia tube drawing period, maintain a relatively stable hemodynamics, not prolong the awakening time and tube drawing time and improve the operation safety.
出处
《系统医学》
2017年第6期10-12,共3页
Systems Medicine
