摘要
局部麻醉药主要通过阻滞神经细胞膜钠离子电流发挥作用,可阻断局部疼痛信号向中枢的传递,具有全身副反应少、止痛效果确切的特点。但临床常用的局部麻醉药作用时间短,单次给药的有效镇痛时间一般不超过8 h。长效局部麻醉药可更好地满足术后镇痛需要,同时可避免全身镇痛药引发的副作用,减少术后并发症。综述局部麻醉药的作用特点、长效局部麻醉药的研究方向及进展。
Local anesthetics inhibit sodium channel currents and block the conduction of pain signal into central nerve system, producing reliable analgesia with minimal systemic adverse effects. However, the duration of local anesthetic is short with an effective analgesia after single injection less than 8 hours. Long-lasting local anesthetics will better meet the demands in post-surgical pain managements, avoid systemic adverse effects associated with systemic analgesics, and redt, ce postoperative complications. This review focused on the action mechanisms of local anesthetics and the approaches and advances in developing long-lasting local anesthetics.
作者
尹芹芹
张文胜
YIN Qinqin ZHANG Wensheng(Department of Anesthesiology,West China Hospital, Sichuan Universiy. Chengdu 610041, China)
出处
《药学进展》
CAS
2017年第8期574-578,共5页
Progress in Pharmaceutical Sciences
