摘要
目的:检测慢性充血性心力衰竭患者血清糖类抗原125(CA125)的表达水平,并分析其临床意义。方法:选取2013年3月至2014年5月信阳职业技术学院附属医院80例慢性充血性心力衰竭患者和80例正常健康志愿者,分别记为疾病组和健康组。检测两组血清CA125的表达水平,并将疾病组对象根据慢性充血性心力衰竭患者的心功能分级进行分组,对比不同心功能分级间血清CA125水平差异。疾病组均给予常规治疗,并随访3年,对比预后良好者和预后不良者纳入研究时血清CA125的水平差异。结果:疾病组血清CA125水平远高于健康组,组间比较,差异具有统计学意义(P<0.05);不同心功能分级患者间血清CA125比较,差异具有统计学意义(P<0.05),其中心功能Ⅳ级者血清CA125水平最高,心功能Ⅲ级者次之,心功能Ⅱ级者血清CA125水平最低;预后不良纳入研究时血清CA125水平远高于预后良好者,组间比较,差异具有统计学意义(P<0.05)。结论:血清CA125在慢性充血性心力衰竭患者中的表达水平异常升高,能够借此评估心功能状态,还可借此评估远期预后效果。
Objective To investigate the expression level of serum carbohydrate antigen 125 （CA125） in chronic congestive heart failure patients and analyze its clinical significance. Methods 80 patients with chronic congestive heart failure and 80 normal volunteers were enrolled in the Affiliated Hospital of Xinyang Vocational and Technical College from March 2013 to May 2014. They were classified as disease group and healthy group. The expression level of serum CA125 in two groups was detected. The patients in the disease group were grouped according to the cardiac function classification in patients with chronic congestive heart failure, and the serum CA125 levels between patients with different cardiac function categories were compared. The patients in the disease group received routine treatment, who were followed up for 3 years, and the difference of serum CA125 levels between the patients with good prognosis and those with poor prognosis were compared. Results The level of serum CA125 in the disease group was much higher than that in the healthy group （P 〈 0.05）. The difference of serum CA125 between patients with different cardiac function classification was statistically significant （P 〈 0.05）. The level of serum CA125 was the highest in the central functional group Ⅳ, followed by the cardiac function class Ⅲ, and the serum CA125 level was lowest in the patients with cardiac function Ⅱ. When the study began, the serum CA125 level of patients with poor prognosis was much higher than those with good prognosis （P 〈 0.05）. Conclusion Serum level of CA125 is abnormally elevated in patients with chronic congestive heart failure, which can be used to assess cardiac function and to assess long-term outcome.
出处
《深圳中西医结合杂志》
2017年第14期52-54,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
血清糖类抗原125
慢性充血性心力衰竭
心功能
Serum carbohydrate antigen 125
Chronic congestive heart failure
Cardiac function
