摘要
萆薢为《中国药典》中粉萆薢和绵萆薢,具有利湿去浊、祛风除痹的功效。临床上主要用于膏淋、关节不利和风湿痹痛等的治疗,疗效显著,应用前景广阔。然而由于萆薢来源混杂,品种混乱以及缺少相关质量评价,使其近年来研究进展缓慢。以往对萆薢的研究主要体现在化学成分上,其主要含有甾体类、二芳基庚烷类和木脂素类等多种化学成分,其中甾体皂苷类成分是其主要成分也是其发挥药理活性的主要物质。近年来研究发现萆薢及其主要成分在降尿酸,抗炎镇痛,抗骨质疏松等方面作用显著,并取得了较大的进展,为临床药物的研究和开发提供了实验性依据。但其发挥药理作用的具体物质和具体机制尚不清晰,有待进一步的探索。笔者通过查阅国内外相关文献,从萆薢的化学成分、质量评价和药理作用等方面对其进行了全面综述,以期为萆薢的进一步研究、开发和应用提供参考。
The Dioscorea hTpoglauca rhizome and D. sporrgiosa rhizome in ＂ China Pharmacopoeia＂ are often used as Bixie in clinically, with the function of removing dampness, clearing away turbidness and dispelling wind to remove pain, and has been widely used in stranguria marked by chyluria, joint stiffness and rheumatic arthralgia. It has obvious curative effect and broad application prospect. However, in recent years the progress of research is slow for its miscellaneous sources, chaotic varieties and lack of relevant quality as- sessment. The previous research on Bixie is mainly reflected in the chemical compositions, mainly including steroids, diarylheptanoids and lignans and so on. Among them, steroidal saponins are the main components and the main effective substances for their pharmacological activities. Recent studies have shown that Bixie and its main components have significant effects in anti-trioxypurine, anti-in- flammation, analgesia and anti-osteoporosis, and have made great progress, providing an experimental basis for the research and development of clinical drugs. But the specific substance and specific mechanism of its pharmacological action are not clear, and need further exploration. By consulting the relevant literature at home and abroad, the author has summarized the chemical constituents, quality evaluation, pharmacological action of Bixie, hoping to provide a reference for further research, development and utilization of Bixie.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2017年第18期3488-3496,共9页
China Journal of Chinese Materia Medica
基金
上海市教育和科研协同创新计划子项目
关键词
萆薢
化学成分
质量评价
药理作用
Bixie
chemical constituents
quality evaluation
pharmacological action
