摘要
目的探究预充右旋美托嘧啶对全麻气管插管老年患者的心血管影响。方法采用回顾性分析的方法,将2014年8月~2016年8月在我院接受全麻气管插管手术治疗的60例患者作为研究对象,并给予随机分组,对照组30例,直接给予麻醉诱导气管插管;干预组30例,麻醉诱导气管插管前给予右旋美托嘧啶预充,对两组患者全麻诱导前后及插管后1min、3min、5min患者的心率(HR)、平均动脉压(MAP)、舒张压(DBP)、收缩压(SBP)及血氧饱和度(SPO2)心血管指标进行综合评价。结果诱导后干预组、对照组患者SBP、DBP呈现下降趋势,与诱导前相比差异具有统计学意义(P<0.05),组间比较差异不具统计学意义(P>0.05);插管后两组患者收缩压呈升高趋势(P<0.05),干预组升高幅度相对较小,与对照组差异不存在统计学意义(P>0.05);插管后3min干预组患者SBP及DBP显著低于对照组(P<0.05),差异有统计学意义;插管后5min内干预组患者HR波动幅度低于对照组(P<0.05),差异有统计学意义。结论对全麻气管插管老年患者给予右旋美托嘧啶预充,能够对全麻气管插管时诱发的心血管反应起到抑制作用,维持血流动力学稳定,具有较高安全性,疗效显著,值得临床推广应用。
Objective To explore the cardiovascular effects of pre prescribed dexmedetomidine on elderly patients undergoing tracheal intubation under general anesthesia. Methods of retrospective analysis were used.60 cases with tracheal intubation under general anesthesia in our hospital from Auguest 2014 to Auguest 2016 were selected as the study object.They were randomly divided into control group and intervention group with 30 cases in each.atients in control group were treated with anesthe^sia induction trachea cannula,and patients in intervention group were treated with Dexmedetomidine precharge before anesthesia induction trachea cannula.The heart rate （HR） of patients with lmin,3min and 5min,mean arterial pressure（MAP）,diastolic blood pressure（DBP）,systolic blood pressure（SBP） and oxygen saturation（SPO2）,cardiovascular parameters before and after general anesthesia induction and after intubation of the two groups were comprehensively evaluated. Results After induction,the intervention group and the control group showed a downward trend in SBP and DBP,compared with before induction,the difference was statistically significant（P 〈 0.05）,the difference between groups was not statistically significant（P 〉 O.05）.After the intubation,the systolic pressure of the two groups showed an upward trend（P 〈 0.05）,and the rising range of the intervention group was relatively small,and there was no statistical difference between the control group and the control group（P 〉 0.05）.After intubation,the SBP and DBP in the 3min intervention group were significantly lower than that in the control group（P 〈 0.05）,which was statistically significant.The fluctuation of HR in the 5min intervention group was lower than that in the control group（P 〈 0.05）.There were statistical significance. Conclusion For elderly patients undergoing tracheal intubation under general anesthesia,dexmedetomidine pretreatment can inhibit the cardiovascular response induced by tracheal intubation under general anesthesia,and maintain hemodynamic stability.It is with high safety,remarkable effect,and it is worthy of clinical application.
出处
《中国医药科学》
2017年第17期180-182,198,共4页
China Medicine And Pharmacy
关键词
右旋美托嘧啶
全麻
气管插管
心血管
血流动力学
Dexmedetomidine
General anesthesia
Trachea intubation
Cardiovascular
Hemodynamics
