摘要
目的对溃疡性结肠炎患者外周血中γ-干扰素(IFN-γ)、白细胞介素10(IL-10)、白细胞介素17(IL-17)的水平和辅助性T细胞17(Th17)比例检测指标的意义进行评价。方法计算机检索PubMed(1996~2016)、CBM(1998~2016)、CNKI(1958~2016)、WangfanData(1999~2016)、VIP(1989~2016)等数据库,对溃疡性结肠炎患者血清IFN-γ、IL-10、IL-17水平和Th17细胞比例指标的随机对照试验(RCT)进行检索,并按照纳入与排除标准筛选文献、评价质量并提取资料后,采用RevMan5.3软件进行Meta分析。结果共纳入20个RCT,1 151例患者。Meta分析结果显示:与对照组比较,溃疡性结肠炎患者外周血IFN-γ、IL-17、Th17上升;外周血IL-10下降。结论 IFN-γ、IL-10、IL-17水平和Th17细胞参与了溃疡性结肠炎的发病过程,有必要开展更深入的研究。
Objective To evaluate the association of interferon-γ（IFN-γ）,interleukin-10（IL-10）,interleukin-17（IL-17）and helper cell T-17（Th17）cells proportion with ulcerative colitis（UC）.Methods Analysis of all related literatures in PubMed（1996-2016）,CBM（1998-2016）,CNKI（1958-2016）,WanfangData（1999-2016）and VIP（1989-2016）was made.Randomized controlled trials involving in serum IFN-γ,IL-10,IL-17 and Th17 cells proportion in UC patients were selected.All statistical tests were performed with RevMan5.3software.Results A total of 20 articles and 1 151 patients were included.The results indicated that IFN-γin UC group was significantly higher than in control group.IL-10 in UC group was significantly lower than that in control group.IL-17 in UC group was significantly higher than that in control group.Th17 cells proportion in UC group was significantly higher than that in control group.Conclusion Existing evidences suggest that IFN-γ,IL-10,IL-17 and Th17contribute to the pathogenesisi of UC.
出处
《临床荟萃》
CAS
2017年第10期891-895,共5页
Clinical Focus
基金
新疆维吾尔自治区自然科学基金资助项目(2014211C033)
