摘要
目的探讨肌肉减少症(肌少症)(sarcopenia,SP)对50岁以上男性骨密度(bone mineral density,BMD)及生命质量(quality of life,Qo L)的影响。方法于山东大学齐鲁医院选取2015年9月-2016年1月50岁以上男性退休职工及健康查体人群177例,利用双能X线吸收检测法(dual energy X-ray absorptionmetry,DXA)测定其腰椎正位及股骨颈BMD、全身体成分,筛选出肌少症患者和非肌少症者,分析两组人群在BMD、体成分、生活方式及生命质量方面的差异及其相关性,使用欧洲5维量表(EuroQol-5 dimensions,EQ-5D)进行生命质量评估。结果肌少症发生率随年龄增长而增加,尤其是80岁以上男性肌少症检出率高达58.33%;肌少症组平均体质量、体质量指数(body mass index,BMI)、腰椎正位及股骨颈BMD、四肢脂肪质量(appendicular fat mass,AFM)均小于非肌少症组。骨骼肌质量指数(skeletal muscle index,SMI)与年龄呈负相关(r=-0.276,P<0.01),与BMI、AFM、腰椎正位及股骨颈BMD呈正相关(r=0.703、0.323、0.205、0.384,P<0.01)。以年龄、身高、体质量、BMI作为控制变量的条件下,SMI与股骨颈BMD仍呈正相关(r=0.236,P<0.01);肌少症组EQ-5D指数平均水平均低于非肌少症组,但两组间差异无统计学意义(P>0.05)。两组在EQ-5D健康描述系统的5个维度中较明显的问题均为疼痛和不舒服项。结论肌少症与骨质疏松症(osteoporosis,OP)之间存在相关性,老年男性人群中常并存肌少症与骨质疏松症,50岁以上男性肌少症患者及高危人群应警惕骨质疏松症的发生。
Objective To investigate the relationship of sarcopenia with bone mineral density （BMD） and the quality of life （QoL） of men ≥50 years.Methods All 177 men,aged 50 to 86 years from Qilu Hospital of Shandong University,were performed dual energy X-ray absorptiometry （DXA） scans to obtain the whole body composition and T score,BMD values of Lumbar spine （L1-4） and femoral neck,and the correlation between sarcopenia with BMD and Qo L was analyzed by Pearson＇s and Spearman＇s correlation analysis.Results The detection rate of sarcopenia was increasing with age and which was as high as 58.33% in men more than 80 years old.The average weight,body mass index （BMI）,appendicular fat mass （AFM）,and BMD of lumber and femur neck in sarcopenia group was lower than that in non-sarcopenia group （P〈0.05）.SMI and age have negative correlation （r =-0.276,P〈0.01） and there is positive correlation between skeletal muscle index （SMI） and BMI,AFM,lumbar and femoral neck BMD （r = 0.703,0.323,0.205,0.384,P〈0.01）.Under the condition of age,height,weight,BMI for control variables,SMI was positively correlated femoral neck BMD （r = 0.236,P〈0.01） The Euro Qol-5 dimensions （EQ-5D） index in sarcopenia group is lower than that in non-sarcopenia group.However,there is no statistical significance.Conclusions Sarcopenia male patients aged over 50 years had a high risk of osteoporosis.They should be alert for osteoporosis.Sarcopenia and osteoporosis always coexist simultaneously.
作者
蒋芳
张晓黎
蒋玲
JIANG Fang ZHANG Xiao-li JIANG Ling(Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China)
出处
《中华骨质疏松和骨矿盐疾病杂志》
CSCD
2017年第5期456-461,共6页
Chinese Journal Of Osteoporosis And Bone Mineral Research
关键词
肌肉减少症
骨密度
生命质量
骨质疏松症
sarcopenia
bone mineral density
quality of life
osteoporosis
