摘要
目的观察溃疡性结肠炎中医证型分类及分布规律。方法收集溃疡性结肠炎患者441例,采用自拟《溃疡性结肠炎的中医证候流行病学调查表》进行一般情况、中医证候、舌象等临床资料的调研,基于因子分析及聚类分析探讨溃疡性结肠炎中医证候规律。结果本研究收集调查问卷的58个症状条目因子分析,KMO统计量为0.916,Bartlett球型检验P<0.0001,适于因子分析。应用最大似然估计法共提取出13个公因子,筛选出具有意义的症状46项,根据病性、病位证素归纳出基本中医证型分为6类。聚类分析显示证型分布比例为:脾胃气虚证占27.66%(122/441),大肠湿热证占26.30%(116/441),脾肾阳虚证占17.69%(78/441),肝郁脾虚证占15.65%(69/441),阴虚肠燥证占8.39%(37/441),血瘀肠络证占4.31%(19/441)。不同病情分期和临床类型的证型分布比例为:大肠湿热证在活动期占48.00%(108/225),脾胃气虚证在缓解期占41.20%(89/216),大肠湿热证在初发型占53.55%(83/155),脾胃气虚证在慢性复发型占45.11%(60/133),脾肾阳虚证在慢性持续型占40.52%(47/116),其他证型分布相当。结论溃疡性结肠炎基本中医证型为6类,活动期以大肠湿热证为主,缓解期以脾胃气虚证为主,初发型以大肠湿热证为主,慢性复发型以脾胃气虚证为主,慢性持续型以脾肾阳虚证为主。
Objective To explore the characteristics of traditional Chinese medicine （TCM） syndrome classification and the distribution pattern of syndrome types in ulcerative colitis. Methods Diagnostic information was collected from 441 cases of ulcerative colitis patients. The general situation, combined with clinical data of disease, TCM syndrome, tongue information were investigated using self-made ＂ulcerative colitis TCM syndrome epidemiology questionnaire＂, and analyzed by factor analysis and clus- ter analysis method. Results Factor analysis was used to analyze the 58 syndrome entries, and the KMO statistic was 0.916, Bartlett ball type test P 〈0.0001. A total of 13 common factors were extracted and 46 significant symptoms were screened out by the maximum likelihood estimation method. According to the disease nature and location, the basic TCM syndromes of ulcerative colitis were divided into 6 categories. Cluster analysis showed that the proportion of syndrome types were as follows ： the syndrome of Pi-Wei qi deficiency was 27.66% （122/441）, the syndrome of large intestine dampness-heat was 26.30% （116/441）,the syndrome of Pi-Shen yang deficiency was 17.69% （78/441）,the syndrome of Gan depression Pi deficiency was 15.65% （69/441）,the syndrome of yin deficiency and intestinal dryness was 8.39% （37/441）, and the syndrome of blood stasis and intestinal collaterals was 4.31% （19/441）. In addition, the distribution of TCM syndromes in different stage and clinical type were analyzed, which the syndrome of large intestine dampness-heat accounted for 48.00% （108/225） during the activity period, the syndrome of Pi-Wei qi deficiency was 41.20% （89/216） in the remission stage, the syndrome of large intestine dampness-heat accounted for 53.55% （83/155~ in first episode types, the syndrome of Pi-Wei qi deficiency accounted for 45.11% （60/133） in chronic recurrence types, the syndrome of Pi-Shen yang deficiency accounted for 40.52% （47/116） in chronic persistent types, and the other syndromes were similar in distribution. Conclusions The basic TCM syndromes of ulcerative colitis show 6 categories. Among them, the syndrome of UC in active stage was mainly large intestine dampness-heat, and the syndrome of Pi-Wei qi deficiency was the main type of UC remission stage. The first episode type of UC was mainly the syndrome of large intestine dampness heat, the chronic recurrence type was mainly the syndrome of Pi-Wei qi deficiency, and the chronic persistent type was mainly the syndrome of Pi-Shen yang deficiency.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2017年第10期1191-1195,共5页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金资助项目(No.81173156)
陕西省科技厅研究资助项目(No.2013JQ4009)
陕西省教育厅研究资助项目(No.2014JK1200)
关键词
溃疡性结肠炎
中医证候
因子分析
聚类分析
ulcerative colitis
Chinese medical syndrome type
factor analysis
cluster analysis
