摘要
目的观察达英-35联合来曲唑治疗难治性多囊卵巢综合征的临床效果。方法研究对象为医院收治的多囊卵巢综合征女性患者90例,随机分为观察组和对照组,每组45例。患者均在使用达英-35进行激素水平调节治疗后,观察组加用来曲唑进行促排卵治疗,对患者服用达英-35前后的黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)水平进行测定;观察2组患者的妊娠、流产、卵巢过度刺激综合征和卵泡黄化素综合征的发生情况。结果在服用达英-35进行基础治疗3个疗程后,2组患者LH、T和LH/FSH值均明显低于治疗前(P<0.01)。观察组患者妊娠率为84.4%(38/45),流产率为2.2%(1/45),均未出现未破裂卵泡黄化素综合征及卵巢过度刺激综合征;对照组妊娠率为62.2%(28/45),流产率为13.3%(6/45),有4例(8.9%)出现卵巢过度刺激综合征,4例(8.9%)出现卵泡黄化素综合征,2组比较差异均有统计学意义(P<0.05)。结论达英-35联合来曲唑能有效减低患者体内的黄体生成素、卵泡刺激素、睾酮素水平,调节患者的性激素水平达正常标准,并且能够促进卵泡发育成熟和排卵,提高妊娠率,降低流产、卵泡黄化素综合征和卵巢过度刺激综合征的发生率,从而治疗难治性多囊卵巢综合征。
Objective To evaluate the efficacy of diane-35 combined with letrozole in the treatment of refractory poly- cystic ovary syndrome. Methods 90 female patients with polycystic ovary syndrome admitted to the hospital were randomly di- vided into observation group and control group,45 cases in each group. Patients in both of the two groups were treated with di- ane-35 for hormone levels. The observation group was treated with letrozole for ovulation induction. The levels of luteinizing hor- mone （LH）,follicle stimulating hormone （FSH） and testosterone （T） were measured before and after treatment with diane- 35. The incidence of pregnancy, abortion, ovarian hyperstimulation syndrome and follicular lutein syndrome were observed in 2 groups of patients. Results The LH ,T and LH/FSH values of the two groups were significantly lower than those before treat- ment after taking diane-35 for 3 courses of treatment （P 〈0.01 ）. The rate of pregnancy in the observation group was 84.4% and the abortion rate was 2.2%. No rupture follicle yellow pigment syndrome and ovarian hyperstimulation syndrome were found. The pregnancy rate was 62.2% and the abortion rate was 13.3% for control group. 4 cases （8.9%） had ovarian hyper- stimulation syndrome,4 cases （8.9%） showed follicular lutein syndrome. The difference between the two groups was statisti- cally significant （P 〈 O. 05 ）. Conclusion diane-35 combined with letrozole can effectively reduce the body~ luteinizing hor- mone, follicle stimulating hormone and testosterone, and regulate the level of sex hormones in patients with normal standards, and can promote follicular maturation and ovulation, improve pregnancy rate, reduce the incidence of miscarriage, follicular yellowing hormone syndrome and ovarian hyperstimulation syndrome, so as to treat refractory polycystic ovary syndrome with good efficacy effect.
作者
陈丽英
CHEN Li-ying(Hanjiang District Chinese Medicine Hospital of Putian City, Fujian 351111, China)
出处
《临床合理用药杂志》
2017年第29期18-20,共3页
Chinese Journal of Clinical Rational Drug Use
