摘要
目的研究初次快速进入高原者在高原低压、低氧环境下肺功能的变化情况,为急性高原病的发病机制提供理论依据。方法 17名乘机初次去高原的青年人分别于入高原前一天、抵达西宁当天、抵达玉树当天及第二天分别进行肺功能检测,检测项目包括VT、RR、MV、MVV、FVC、FEV1、FEV1/FVC%、PEF、FEF25%、FEF50%、FEF75%、MMEF。结果 FVC随海拔升高而下降;FEV1/FVC%、PEF、FEF25%、FEF50%、MMEF随海拔升高而升高;VT及FEV1不随海拔升高而变化;RR、MV、MVV、FEF75%均只有北京与玉树第二天数据升高具有统计学意义,北京与西宁、北京与玉树当天、西宁与玉树当天、西宁与玉树第二天数据升高均不具有统计学意义。结论平原地区人们快速进入高原后机体会发生一系列代偿性改变,其中以呼吸系统变化最明显最快速,客观表现为肺功能的变化。
Objective To investigate the changes of pulmonary function in people arriving at plateau rapidly for the first time, and to provide theoretical basis for the pathogenesis of acute high altitude diseases. Methods 17 young people who went to the plateau for the first time by plane were tested for pulmonary functions in Beijing, on the first day arriving at Xining, on the first day arriving at Yushu and the next day arriving at Yushu. The test items in-cluded VT, RR, MV, MVV, FVC, FEV1 , FEV1/ FVC%, PEF, FEF25%, FEF50%, FEF75%, and MMEF. Results FVC decreased significantly with increasing altitude. FEV1/ FVC%, FEF25%, FEF50%, PEF and MMEF increased significantly with increasing altitude. VT and FEV1 remained unchanged with increasing altitude. The values of RR, MV, MVV and FEF75% increased significantly only at the next day in Yushu when compared with Beijing, but no obvious changes when compared with Xining and on the first day in Yushu. When the values of the first day in Yushu compared to Xining and Beijing, RR, MV, MVV and FEF75% showed a non-significant increase. Conclusion There are a series of compensatory changes in human body when the young people living at low altitude rapidly enter into plateau, among which the most obvious and rapid change occurs in respiratory system and is mani-fested in pulmonary function.
出处
《临床肺科杂志》
2017年第11期1944-1947,共4页
Journal of Clinical Pulmonary Medicine
关键词
平原
高原
肺功能
快速
high altitude
low altitude
pulmonary function
rapidly
