摘要
目的观察糖尿病合并冠心病患者不同中医证型血清脂联素(adiponectin,APN)和超敏C反应蛋白(hypersensitive3 C-reactive protein,hs-CRP)的水平,了解APN和hs-CRP在糖尿病合并冠心病不同证型患者中的变化规律。方法收集符合糖尿病合并冠心病西医诊断标准和中医诊断标准的气阴两虚组、痰浊闭阻组患者各30例,正常对照组30例,检测患者和正常人群血清APN、hs-CRP水平和FPG、TC、TG、LDL、HDL、Hb A1c水平,运用统计学方法分析组间差异及指标之间的相关性。结果对照组APN和hs-CRP值分别为(10.73±1.44)μg/m L和(1.14±0.31)mg/L,气阴两虚组APN和hs-CRP值分别为(6.72±1.22)μg/m L和(3.91±2.75)mg/L,痰浊闭阻组APN和hs-CRP值分别为(7.41±1.26)μg/m L和(6.92±3.38)mg/L。气阴两虚组和痰浊闭阻组APN较对照组明显降低,差异有显著统计学意义(P<0.01),气阴两虚组和痰浊闭阻组hs-CRP较对照组明显升高,差异有显著统计学意义(P<0.01),气阴两虚组APN、hs-CRP水平低于痰浊闭阻组,差异有统计学意义(P<0.05,P<0.01)。结论 APN和hs-CRP与糖尿病合并冠心病气阴两虚证关系密切。APN和hs-CRP血清水平对糖尿病合并冠心病中医治疗有参考意义,应特别注意益气养阴。APN和hs-CRP对糖尿病合并冠心病辨证分型具有一定参考价值。
Objective To observe the levels of blood serum adiponectin（APN） and high-sensitive C-reactive protein（hs-CRP）, illuminate the relationship between TCM syndromes with APN and hs-CRP Levels in diabetes mellitus（DM） patients with coronary heart disease（CHD）. Methods 60 patients（deficiency of Qi-Yin group and blockade of phlegm-turbidity group） and 30 normal people（normal control group） were collected according to the diagnostic criteria of DM with CHD Western medicine and TCM. The levels of blood serum APN, hs-CRP, FPG, TC, TG, LDL, HDL and Hb A1 c were tested in all groups, and the relationship between indicators and all groups were analyzed by the statistical method. Results The levels of APN and hs-CRP in control group were（10.73 ±1.44） μg/m L and（1.14 ±0.31） mg/L, respectively. The levels of APN and hs-CRP in deficiency of Qi and Yin group were（6.72±1.22） μg/m L and（3.91±2.75） mg/L, respectively. The levels APN and hs-CRP in blockade of phlegm-turbidity group were（7.41±1.26） μg/m L and（6.92±3.38） mg/L, respectively. The APN and hs-CRP in deficiency of Qi-Yin group and blockade of phlegm-turbidity group were significantly lower than the control group, there was significant difference（all P〈0.01）, and the levels of APN and hs-CRP in deficiency of Qi and Yin group were significantly lower than those in the control group（P〈0.01）. Conclusion The deficiency of Qi and Yin syndrome was closed related with APN, hs-CRP in DM patients with CHD. Therefore, APN and hs-CRP have some reference value for syndrome differentiation and treatment of DM with CHD.
出处
《湖南中医药大学学报》
CAS
2017年第10期1106-1109,共4页
Journal of Hunan University of Chinese Medicine
基金
国家自然科学基金面上项目(81373551)
关键词
糖尿病合并冠心病
气阴两虚
痰浊闭阻
APN
hs-CRP
相关性
diabetes mellitus with coronary heart disease
deficiency of Qi-Yin
blockade of phlegm-turbidity
APN
hs-CRP
correlation
