摘要
目的本研究旨在研究超声造影(contrast-enhanced ultrasound,CEUS)技术在前列腺特异性抗原(prostate-specific antigen,PSA)水平持续升高(4 ng/ml≤PSA<10 ng/ml)以及之前经直肠超声(trans-rectal ultrasound,TRUS)引导下随机活检阴性患者中检测前列腺肿瘤病灶的作用。方法本实验纳入180个受试者。A组患者再次给予前列腺穿刺活检,B组患者给予CEUS穿刺活检。结果在第二次活检中,在A组90例中发现前列腺腺癌组织学诊断的共有20例(22.2%),在B组90例中共发现43例(47.8%)(P<0.01)。CEUS穿刺活检敏感性为93.2%,特异性为89.2%,阳性预测值(positive predictive value,PPV)为86.6%,阴性预测值(negative predictive value,NPV)为94.0%,准确性为91%。结论在先前经TRUS引导下穿刺活检阴性患者中,CEUS穿刺活检显示出了指导癌症病灶活检的潜力,CEUS定向活检技术可增加前列腺癌的检出率。
Objective To investigate the value of contrast-enhanced ultrasound（ CEUS） in the detection of prostate tumor foci in patients with persistently elevated prostate-specific antigen（ PSA） levels（ in the range of≥4 ng/ml to 〈 10 ng/ml） and prior negative random trans-rectal ultrasound（ TRUS）-guided biopsy. Methods 180 patients of suspected prostate cancer were included in the study. Patients in group A underwent the second random prostate biopsy,and patients in group B underwent a CEUS examination and samples targeted on suspicious areas were associated to the random biopsy. Results In the second biopsy,20 of 90（ 22. 2%） patients were diagnosed with prostate cancer in group A,and 43 of 90 cases（ 47. 8%） in group B were diagnosed with prostate cancer. Conclusions CEUS based blood-flow grading scale is a reliable tool to predict patients with previously negative TRUS biopsy. In the future,a CEUS directed biopsy could be prospectively compared with a saturation biopsy procedure.
出处
《泌尿外科杂志（电子版）》
2017年第2期11-15,共5页
Journal of Urology for Clinicians(Electronic Version)
基金
山东省自然科学基金(No.ZR2013HL070)
烟台市科技发展计划(No.2014WS007)资助
