摘要
目的探讨吡非尼酮(PFD)联合高压氧疗对老年慢性硬膜下血肿(CSDH)术后复发的影响。方法选择2013年1月至2017年2月收治的42例CSDH老年患者作为研究对象,随机分为对照组和观察组,每组21例。对照组采用单纯钻孔引流术,观察组在对照组的基础上予吡非尼酮及高压氧治疗。观察两组患者术后1个月、3个月、6个月头部CT的颅内残存血肿腔有无差异,并比较术后6个月的复发情况。结果观察组的颅内血肿腔残存明显低于对照组,疗效明显优于对照组,两者复发情况差异有统计学意义(P<0.05)。结论吡非尼酮联合高压氧疗能降低老年慢性硬膜下血肿术后复发率。
Objective To explore the clinical effect of pirfenidone（PFD）combined with hyperbaric oxygen on postoperative recurrence of chronic subdural hematoma（ CSDH） in elderly patients. Methods Four-two elderly patients who suffered from CSDH and admitted to hospital from January,2013 to February,2017 were recruited in current research. Patients were randomly divided into control group and observation group,with 21 cases in each.The control group were treated by burr-hole and drainage,and based on which the observation group were given PFD combined with hyperbaric oxygen.The intracranial residual hematoma which was shown by head CT images at 1 months,3 months and 6 months after operation was observed between the two groups,respectively.Meanwhile,the recurrence was compared 6 months after operation between the two groups.Results The intracranial residual hematoma in the observation group was less than that in the control group,the curative effect of the observation group was better than that in the control group,and the difference of recurrence between the two groups was statistically significant（ P〈0.05）.Conclusion PFD combined with hyperbaric oxygen can reduce the postoperative recurrence rate of CSDH in elderly patients.
出处
《右江医学》
2017年第5期544-547,共4页
Chinese Youjiang Medical Journal
基金
广西卫生和计划生育委员会科研课题(Z2015635)
