摘要
目的比较局部进展期胃癌根治术后同步放化疗及与单纯化疗的临床疗效与安全性。方法回顾2008年1月至2011年12月沛县人民医院126例局部进展期胃癌根治术后患者临床资料,其中63例术后采用放疗同步替吉奥序贯4~6周期奥沙利铂联合卡培他滨(XELOX方案)化疗(放化疗组)。另63例术后仅予以6~8周期XELOX方案化疗(化疗组)。比较两组患者的不良反应发生率,并统计患者5年内生存率及复发率。结果两组患者2年生存率差异无统计学意义(P>0.05),3年以上生存率放化疗组高于化疗组(P<0.05)。复发率放化疗组低于化疗组(P<0.05)。患者的不良反应主要表现在胃肠道、血液系统及肝肾功能方面。与化疗组相比,放化疗组患者Ⅰ~Ⅲ级不良反应发生率较高(P<0.05),Ⅳ级不良反应两组差异无统计学意义(P>0.05)。结论局部进展期胃癌根治术后同步放化疗较单纯化疗可以延长患者5年生存率,降低复发率,不良反应可以耐受。
Objective To compare the clinical efficacy and safety of concurrent chemoradiotherapy and chemotherapy alone after D2 radical gastrectomy for locally advanced gastric cancer.Methods A total of 126 cases of locally advanced gastric cancer were divided into two groups： concurrent chemoradiotherapy group （the RCT group） and chemotherapy group （the CT group）,and each group contained 63 cases.The RCT group received radiotherapy concurrent with capecitabine chemotherapy,and the followed by 4 ~ 6 cycles of XELOX chemotherapy;however,the CT group only received 6 ~ 8 cycles of XELOX chemotherapy.The incidence of side effects,survival rates in 5 year and metastasis rate were compared between the two groups.Results The 2-year survival rates of the 2 groups had no significant difference （P〈0.05）,while the 3-year survival rate of the RCT group was higher than that of the CT group （P〈0.05）.The 5-year survival rate of the RCT group was 61.90%,which was significantly higher than that of the CT group （50.79%）.The metastasis rate of the RCT group was lower than that of the CT group,and the difference was statistically significant （P〈0.05）.The side effects of the 2 groups were gastrointestinal toxicity,abnormal liver function,renal dysfunction and blood toxicity.The incidence of gradeⅠ-Ⅲwas significantly higher than that of the CT group,although the incidence of grade Ⅳ was higher than that of the CT group,the difference was not significant （P〉0.05）.Conclusions Concurrent chemoradiotherapy after radical gastrectomy for D2 locally advanced gastric cancer was better than chemotherapy alone,it can improve 5-year survival rate,reduce relapse rate,and the side effects can be tolerated.
出处
《中国肿瘤外科杂志》
CAS
2017年第5期304-307,共4页
Chinese Journal of Surgical Oncology
关键词
进展期胃癌
手术后
同步放化疗
化疗
疗效比较
Locally adwnced gastric cancer
Postoperation
Concurrent chemoradiotherapy
Chemotherapy
Comparison on therapeutic effect
