摘要
目的:评价小剂量低分子肝素钙对脓毒症患儿的临床疗效及安全性。方法:92例脓毒症患儿随机分为对照组46例,试验组46例。两组患儿均给予吸氧、抗感染、治疗原发病等常规治疗,试验组在常规治疗基础上加用低分子肝素钙,10IU/kg每12h皮下注射。比较患儿凝血功能及临床疗效。结果:治疗后试验组临床总有效率(95.65%)明显高于对照组(69.57%),差异具有统计学意义P<0.05;治疗后两组APTT、PT及TT时间均有下降,但差异不显著(P>0.05),试验组APTT、PT及TT时间均显著低于对照组,差异具有统计学意义(P<0.05);治疗后两组FIB水平升高(P<0.05),且试验组FIB水平显著高于对照组,差异具有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论:小剂量低分子肝素钙能够提高脓毒症患儿多余的临床治疗疗效,改善凝血功能。
Objective：To evaluaie the curative efficacy and safety of small dose of low-molecularweight heparin calcium for the treatment of children with sepsis. Methods： 92 cases of children with sepsis were randomly divided into control group（46 cases） and experiment group（46 cases）. Patients in both groups were given oxygen, anti-infection, treatment of the original disease and other conventional treatment. According to the control group, patients in the experiment group were given low molecular weight heparin calcium at 10 IU/kg every 12 hours by subcutaneous injection. After treatment, coagulation function and clinical curative effect were compared. Results： The total clinical efficacy of the treatment group （95.65%） was significantly higher than that of the control group （ 69.57% ）, the difference was statistically significant （ P〈0.05 ）. After treatment, the PT, TY and APTY in 2 groups were slightly decreased, but not statistically different （ P〈0.05 ）. The AprIT, PT and TY in patients of the treatment group were significantly lower than that in the control group （ P〈0.05 ）. The FIB levels were significantly increased with time and the values in experiment group were significantly higher than that in control group （ P〈0.05 ）. There was no significant difference in adverse reactions between the two groups （ P 〉 0.05 ）. Conclusion： Small dose of low molecular weight heparin calcium can improve the clinical treatment efficacy, improve the coagulation function in children with sepsis.
出处
《河北医学》
CAS
2017年第10期1732-1735,共4页
Hebei Medicine
基金
深圳市科技创新委员会2013年知识创新计划
(编号:JCYJ20130329161409793)
关键词
肝素钙
凝血功能
脓毒症
疗效
Heparin calcium
Coagulation function
Sepsis
Curative efficacy
