摘要
组蛋白去乙酰化酶5(HDAC5)属于Ⅱa类HDAC家族成员,其通过催化组蛋白去乙酰化导致局部染色质结构呈压缩/关闭状态而抑制基因转录;HDAC5还可催化其他蛋白质去乙酰化而调控生物大分子之间的相互作用。由此,HDAC5广泛参与调控基因转录、细胞信号传导、细胞衰老和细胞凋亡等重要生理、病理过程,并在细胞分化和肿瘤发生过程中发挥重要作用。本文综述了新近有关HDAC5结构、功能和其参与疾病发生发展的研究进展。
HDAC5（histone deacetylase5） is a member of histone deacetylase class Ⅱa and catalyzes deacetylation of histone, which results in gene transcription inhibition through condensing regional chromatin. Furthermore, HDAC5 regulates interaction between biomacromoleculars through deacetylating proteins other than histone. Thereby, HDAC5 plays important roles in cell differentiation, tumorigenesis, regulation of gene transcription, cell signal transduction, cell aging and apoptosis. Here, we reviewed the recent advancement of HDAC5 on its structure, functions, as well as its roles in human disease.
作者
王发玲
王艳林
曹春雨
WANG Faling Wang yanlin CAO Chunyu(Three Gorges University Medical College, Yichang 443002, China Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Yichang 443002, China)
出处
《生命的化学》
CAS
CSCD
2017年第4期471-476,共6页
Chemistry of Life
基金
湖北省宜昌市医疗卫生科技项目(Z2017005)
肿瘤微环境与免疫治疗湖北省重点实验室(三峡大学)开放基金(2016KZL01)
关键词
HDAC5
组蛋白去乙酰化
肿瘤发生
基因转录
histone deacetylase 5
histone deacetylation
tumorigenesis
gene transcription
