摘要
目的:研究预先联合使用右美托咪定和地佐辛对罗库溴铵注射痛的影响。方法:拟行全身麻醉的择期手术患者120例,随机分为4组,每组各30例,分别为对照组(C组)、右美托咪定组(Y组)、地佐辛组(D组)和右美托咪定联合地佐辛组(L组),分别给予生理盐水5 m L、右美托咪定0.5μg/kg、地佐辛0.1 mg/kg、右美托咪定0.5μg/kg+地佐辛0.1 mg/kg。记录患者注射痛发生率、推注芬太尼后呛咳发生率以及诱导期间血压和心率的变化。结果:与C组比较,Y组、D组、L组注射痛和呛咳发生率降低(P<0.05);与Y组、D组比较,L组注射痛和呛咳发生率更低(P<0.05)。麻醉诱导后,Y组、L组比C组、D组心率(heart rate,HR)慢且平均动脉压(mean arterial pressure,MAP)降低幅度更小(P<0.05)。结论:麻醉诱导前联合使用右美托咪定和地佐辛比单独使用其中一种能够进一步减少罗库溴铵注射痛的发生,促进麻醉诱导中循环的稳定,降低呛咳发生率。
Objective： To investigate the effect of pretreatment with dexmedetomidine and dezocine on rocuronium injection pain. Methods：120 cases of patients under general anaesthetic for elective surgery were randomly divided into 4 groups（ n = 30） ： control group（ group C）,dexmedetomidine group（ group Y）,dezocine group（ group D） and dexmedetomidine and dezocine unions group（ group L）. They received normal saline 5 ml,dexmedetomidine 0. 5μg/kg,dezocine 0. 1 mg/kg,and dexmedetomidine 0. 5 μg/kg combined with dezocine 0. 1mg/kg respectively.The incidences of injection pain and fentanyl-induced cough were observed and the changes of blood pressure（ BP） and heart rates（ HR） were monitored and recorded. Results： Compared with group C,the incidences of injection pain and fentanyl-induction cough in group Y,group D,and group L significantly decreased（ P 〈 0. 05）; the incidences of injection pain and fentanyl-induction cough in group L were lower than those in group Y and group D（ P 〈 0. 05）. After anesthesia induction,HR and the amplitude of mean arterial pressure（ MAP） in group Y and L were significantly slower than those in group C and D（ P 〈 0. 05）. Conclusion： Pre-injection of dexmedetomidine and dezocine before anesthesia induction can significantly reduce rocuronium injection pain,promote the stability of anesthesia induction circulation,and reduce the incidence of fentanyl-induction cough.
出处
《包头医学院学报》
CAS
2017年第9期28-30,共3页
Journal of Baotou Medical College
