摘要
目的探讨药物球囊在桥血管远端吻合口病变中应用的疗效和安全性。方法选择桥血管远端吻合口病变患者28例,分为观察组16例(应用药物球囊扩张治疗、视情况必要时应用传统球囊预处理靶病变),对照组12例(应用传统球囊扩张治疗,包括普通球囊或切割球囊),术后随访6个月,观察2组即刻手术效果、远期预后,临床心血管事件发生情况等。结果 2组介入治疗中均无冠状动脉穿孔、心包填塞、急性血栓事件发生。观察组与对照组手术成功率比较无统计学差异(87.5%vs 91.7%,P=1.000),2组术前及术后即刻病变血管最小内径(MLD)无显著差异(P>0.05),观察组随访MLD明显大于对照组[(1.9±0.3)mmvs(1.6±0.3)mm,P=0.021];随访期间,2组无心性死亡、非致死性心肌梗死、靶病变血运重建。结论药物球囊行冠状动脉腔内成形术治疗桥血管远端吻合口病变疗效良好、安全。
Objective To study the efficacy and safety of drug-coated balloon（DCB）in interventional therapy for distal graft anastomosis lesions following coronary artery bypass grafting（CABG）.Methods Twenty-eight patients with distal graft anastomosis lesions following CABG were divided into observational group（n=16）and control group（n=12）.The patients in observational group received DCB therapy and traditional ballon pretreatment of target lesions in case of need while those in control group received traditional ballon dilation therapy.The patients were followed up for 6 months,during which the operation efficacy,long-term outcome and incidence of cardiovascular events were recorded.Results No coronary perforation,pericardial tamponade and acute thrombus occurred in two groups during the interventional therapy.No sigflificant difference was found in the operation success rate between the two groups（87.5% vs 91.7%,P=1.000）and in the instant minimal lumen diameter（MLD）between the two groups before and after operation（P〉0.05）.The MLD was significantly longer in observational group than in control group（1.9±0.3 mmvs 1.6±0.3 mm,P=0.021）.No cardiaogenic death,nonfatal myocardial infarction and revascularization occurred in two groups during the follow-up period.ConclusionDCB is effective and safe for distal graft anastomosis lesions following CABG.
出处
《中华老年心脑血管病杂志》
CAS
2017年第11期1157-1160,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
首都卫生发展科研专项(首发2011-6031-02)
