摘要
目的:探讨疏血通注射液联合巴曲酶治疗急性进展性脑梗死的临床疗效及对血清hs-CRP、IL-6水平的影响。方法:选择82例急性进展性脑梗死患者为研究对象,根据随机数字表法分为观察组与对照组,每组41例,对照组予巴曲酶治疗,观察组联合应用疏血通注射液,比较两组患者治疗前后NIHSS评分、BI评分及血清hs-CRP、IL-6水平的变化。结果:观察组与对照组患者治疗后NIHSS评分分别为(9.81±1.94)、(13.33±2.38)分,均较治疗前的(18.78±3.51)、(17.64±4.86)分明显降低,BI评分为(62.46±11.16)、(53.25±10.72)分,较治疗前的(31.58±12.87)、(32.64±10.96)分明显提高,且观察组优于对照组,差异有统计学意义(P<0.05);治疗后,观察组治疗有效率为80.49%,明显高于对照组的63.41%,差异有统计学意义(P<0.05);观察组与对照组患者治疗后,血清hs-CRP、IL-6水平分别为(12.26±2.21)mg/L、(19.62±6.48)ng/L和(15.43±3.18)mg/L、(24.17±6.06)ng/L,均较治疗前的(19.62±3.44)mg/L、(42.56±10.47)ng/L和(20.26±4.08)mg/L、(41.92±11.58)ng/L明显降低,且观察组明显低于对照组,差异有统计学意义(P<0.05)。结论:疏血通注射液联合巴曲酶治疗急性进展性脑梗死具有较好的临床疗效,可显著降低患者血清hs-CRP、IL-6水平并改善神经功能缺损程度,改善日常生活活动能力。
Objective ：To investigate the clinical efficacy of Shuxuetong Injection combined with batroxobin in the treatment of acute progressive cerebral infarction and its effect on the levels of serum hs-CRP and IL-6. Methods ：82 patients with acute progressive cerebral infarction were selected as the subjects. They were randomly divided into observation group and control group,41 cases in each group,the control group was treated with batroxobin treatment,the observation group based on that combined with application of Shuxuetong Injection,the changes of NIHSS score,BI score and serum hs-CRP,IL-6 levels of the two groups were compared before and after treatment. Results ：The NIHSS score in observation group and control group after treatment were（9.81±1.94）,（13.33±2.38）points,decreased significantly than before treatment which were（18.78±3.51）,（17.64±4.86）points,BI score was（62.46±11.16）and（53.25±10.72）points,significantly improved than before treatment which were（31.58±12.87）and（32.64±10.96）points,and the observation group were better than the control group,the difference was of statistically significant（P〈0.05）;after treatment,the effective rate of the observation group was 80.49%,significantly higher than that of the control group,the difference was of statistically significant（P〈0.05）;after treatment,the serum hs-CRP,IL-6 level in observation group and control group were（12.26±2.21）mg/L,（19.62±6.48）ng/L and（15.43±3.18）mg/L,（24.17±6.06）ng/L,they were decreased than before treatment which were（19.62±3.44） mg/L,（42.56±10.47） ng/L and（20.26±4.08） mg/L,（41.92±11.58）ng/L,and the observation group was significantly lower than the control group,the difference was of statistically significant（P〈0.05）. Conclusion ：Shuxuetong Injection combined with batroxobin in treatment of acute progressive cerebral infarction has good clinical curative effect,and can significantly reduce the serum hs-CRP and IL-6 levels and improve the degree of neurologic impairment and improve the ability of daily life.
出处
《辽宁中医药大学学报》
CAS
2017年第10期154-156,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
陕西省科技厅研究项目重大项目(2013KTZB03-02-02)
关键词
疏血通注射液
巴曲酶
脑梗死
疗效观察
Shuxuetong Injection
enzyme
cerebral infarction
curative ettect observation
