摘要
目的观察不同首剂量阿加曲班在出血倾向连续性肾脏替代治疗(CRRT)患者中的抗凝效果。方法选择141例接受CRRT治疗的患者,根据不同首剂量将患者分为0μg/kg组、20μg/kg组、30μg/kg组、40μg/kg组,各组维持量均为24μg/(kg·h),观察各组治疗前、中、治疗结束前患者活化部分凝血活酶时间(APTT);治疗中、治疗结束时血滤器、血路管凝血情况。结果 30μg/kg组APTT水平变化较平稳,在体外基本维持APTT于使用阿加曲班注射液前1.5~2.5倍左右,CRRT治疗时静脉压稳定而且抗凝效果好。结论首剂量30μg/kg阿加曲班可使CRRT顺利进行,且无凝血及出血倾向。
Objective To investigate the anticoagulant effect of different initial dose of argatroban in patients with hemorrhage tendency undergoing continuous renal placement therapy （CRRT）. Methodsone patients of hemorrhage tendency undergoing CRRT were divided into four groups according to the different initialdose： 0μg/kg group,20μg/kg group,30μg/kg group and 4 0μg/kg group,each group maintena h）. The activated partial thromboplastin time（APTT） was observed before, during and after treatment. Thecoagulation hemofilter and blood pipeline were observed during and after treatment. Results The 30μg/kg group kept relatively stable and APTT maintained between 1. 5 and 2. 5 times than pressure was stable and anticoagulant was effective. Conclusion The initial dose in 30 Ag/kg successful withnot coagulation and bleeding trends.
作者
李莹屏
马志刚
黄文辉
黄军悦
薛嵘
卢守燕
Li Yingping Ma Zhigang HuangWcnhui HuangJunyuc XueRong Lu Shouyan(Department of Nephrology Gansu Provincial People’s Hospital,Lanzhou 730000 Chin)
出处
《临床荟萃》
CAS
2017年第11期961-964,共4页
Clinical Focus
关键词
肾透析
抗凝药
阿加曲班
renal dialysis
anticoagulants
argatroban anhydrous
