摘要
目的:分析血清B型钠尿肽(BNP)浓度变化对急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入(PCI)术后预后的预测价值。方法:选取130例发病12 h内行PCI治疗的STEMI患者,通过荧光免疫法测定所有患者治疗前、发病24h、发病1周血清BNP水平,根据发病24 h血清BNP水平将患者分为A(≤100 pg/m L)、B(<100~400 pg/m L)、C(>400 pg/m L)三组,比较各组入院时Gensini评分、PCI术后1周左室射血分数(LVEF)、左心室舒张末期容积(LVEDV)、左心室壁运动积分指数(LVWMSI)及术后6个月预后(主要心血管不良事件)情况。结果:A组Gensini评分最低,B组居中,C组Gensini评分最高;C组入院时Gensini评分、CI术后1周LVWMSI、随访6个月再发心肌梗死、心力衰竭、心律失常发生率均显著高于A、B组,B组以上指标均明显高于A组(P<0.05);Pearson相关性分析显示患者24 h血清BNP水平与LVWMSI呈显著正相关(r=0.728,P<0.01)。结论:血清BNP水平可有效反映STEMI患者PCI术后心功能,对近期不良心血管事件有一定的预测价值。
Objective： To analyze the clinical value of changes of serum type B natriuretic peptide （BNP） concentration for the prognostic prediction of patients with acute ST segment elevation myocardial infarction （STEMI） after percutaneous coronary intervention （PCI）. Methods： 130 cases of patients with STEMI treated by PCI within 12h after attack were selected. The serum BNP level was determined by fluorescence immunoassay before treatment, in 24 h after attack and in 1 week after attack. According to the serum BNP level in 24h after attack, the patients were divided into group A（〈 100 pg/mL）, group B（100,-400 pg/mL） and group C（〉400 pg/mL）. The Gensini score on admission, the left ventricular ejection fraction （LVEF）, the left ventricular end diastolic volume （LVEDV） and left ventricular wall motion score index （LVWMSI） in 1 week after PCI and the incidence of major adverse cardiovascular events） in 6 months after operation were compared among groups. Results： The Gensini score in group A was the lowest, group B was middle, and Gensini score was highest in group C. The Gensini score on admission, LVWMSI at 1 week after PCI operation, the incidence rate of myocardial infarction, heart failure and arrhythrniaatfoUow-up for 6 months in group C were significantly higher than those ingroup A and group B, and the indexes ingroup B were significantly higher than those in group A （P〈0.05）. Pearson correlation analysis showed that the 24 h serum BNP level of patients was significantly positively correlated with LVWMSI （r=0.728, P〈0.01）. Conclusion： Serum BNP level can effectively reflect the cardiac function of patients with STEMI after PCI, and it is of certain value in prediction of the recent adverse cardiovascular events.
出处
《现代生物医学进展》
CAS
2017年第31期6170-6174,共5页
Progress in Modern Biomedicine
基金
福建省自然科学基金项目(2013J01305)
关键词
急性ST段抬高型心肌梗死
B型钠尿肽
预后
Acute ST segment elevation myocardial infarction
Type B natriuretic peptide
Prognosis
