摘要
肺癌已成为发病率和死亡率增长最快,对人群健康和生命威胁最大的恶性肿瘤之一,而肺癌转移是治疗失败和患者死亡的主要原因。究其深层原因是由于目前对肺癌转移的发生机制尚不完全明了。因此根据动物和模型的特点建立合适的肺癌转移动物模型可为肺癌转移的发病原因、发病机制、预防策略及临床早期诊断和药物疗效评价等提供研究基础。本文就实验动物选择、不同部位转移模型建立方法及其在科研领域中的应用进展作一综述。
Lung cancer has become one of the most common malignant tumors with the highest morbidity and mortality, and the greatest threat to people’s health and life; while lung cancer metastasis is the major cause of treatment failure and the mortality of lung cancer patients. The main reason of the phenomenon is because the mechanism of lung cancer metastasis is not fully understood. It is advisable to choose appropriate lung cancer metastasis animal model according to both the characteristics of the animal and the model. Lung cancer metastasis animal models can provide the research basis which is helpful to investigate the pathogenesis, prevention strategies of lung cancer metastasis, clinical early diagnosis and the drug efficacy evaluation. This paper aims to introduce how to choose different immune defi cient mice, how to build in situ metastasis, lymphatic metastasis, hematogenous metastasis, bone metastasis, brain metastasis and visceral metastasis animal models, and their applications in science research.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2017年第11期769-773,共5页
Cancer Research on Prevention and Treatment
基金
国家自然科学基金(81472180)
同济大学中央高校基本科研业务费专项资金-学科交叉类项目(1501219101)
关键词
肺癌
动物模型
转移
免疫缺陷
Lung cancer
Animal models
Metastasis
Immune defi ciency
