摘要
目的了解2015-2016年上海市某手足口病定点医院患者分布、病原学情况以及气象因素对该院手足口病人数的影响。方法收集2015-2016年上海市某手足口病定点医院手足口病就诊病例,分析疾病分布;并采集患者咽拭子/肛拭子标本,检测病原;收集2015-2016年上海地区气象资料,分析气象因素对某手足口病定点医院就诊人数的影响。结果 2015-2016年上海市某手足口病定点医院共报告16 447例手足口病病例,其中男性患者多于女性患者,5岁以下患者为12 474例,占总患者人数的75.84%,是手足口病的重点防治对象;手足口病全年均有发生,发病高峰位于6~7月,托幼机构、学校、家庭是手足口病发病的主要场所,且这些场所易发生手足口病聚集性事件。该病病原体主要包括肠道病毒71型(EVA71)、柯萨奇病毒A16型(CV-A16)、柯萨奇病毒A10型(CV-A10)、柯萨奇病毒A6型(CV-A6)。气象资料(温度、相对湿度、水汽压)会影响该院手足口病入院人数,与入院人数呈正效应的气象区间为:温度为14.3~25.3℃以及<1.2℃,湿度为<59%以及>83%。水汽压为11.4~25.9hPa。结论上海市某手足口病定点医院入院人数报告例数较高,呈上升趋势,6~7月为疾病高发季节,5岁以下儿童高发,托幼机构、学校、家庭为该病发病主要场所;EV-A71、CV-A16、CV-A6为主要病原体;气象因素可影响手足口病的流行特征。
Objective To study the distributions and etiological features of diagnosed hand,foot,and mouth disease（HFMD）in a designated hospital from 2015 to 2016in Shanghai,China. Methods Clinical and epidemiologic data were collected from a designated hospital of HFMD in Shanghai from 2015 to 2016 to analyze the distribution of HFMD.Throat swab and anal swab of patients were collected to detect the etiology distribution of HFMD.The meteorological data of Shanghai from 2015 to 2016 were also collected to analyze the influence on HFMD occurrence. Results From 2015 to 2016,a total of 16 447 HFMD cases were reported from the designated hospital.Of all the patients,children under 5years of age accounted for 75.84%,and more male patients were diagnosed than female patients.HFMD was epidemic throughout the year,peaked in June and July.Nursery institutions,schools,and families are the main places where HFMD occurred,where HFMD aggregation events easily occurred.Enterovirus 71（EV-A71）,coxsackie virus A16（CV-A16）,Coxsackie virus A10（CV-A10）,and coxsackie virus A6（CV-A6）were the main pathogens of the disease.Meteorological data（temperature,relative humidity and water vapor pressure）could affect the number of HFMD.We further identified a meteorological interval which showed positive effect on the admission number of patients.The temperature was between 14.3-25.3 ℃ and 1.2 ℃ below,humidity was below 59% or above83%,and water vapor pressure was between 11.4-25.9h Pa. Conclusions There was a rising trend of HFMD patients reported from the designated hospital.Reported cases peaked in June and July.There was a high incidence of HFMD in children under 5 years of age.Nursery institutions,schools,and families were the main occurring places of HFMD;EV-A71,CV-A16,and CV-A6 were the main pathogens of the disease,and there was a rising trend of CV-A6 infection.Meteorological factors may affect the occurrence of HFMD.
出处
《中国病毒病杂志》
CAS
2017年第5期366-370,共5页
Chinese Journal of Viral Diseases
基金
军队重大研究计划(AWS11L009)
2015年度杨浦区卫生计生委
科委科研青年项目(YP15Q13)
关键词
手足口病
病原学资料
气象因素
流行病学
Hand,foot,and mouth disease
Etiological characteristics
Meteorological factors
Epidemiology
