摘要
目的:了解安徽省肿瘤医院(以下简称"该院")严重的药品不良反应(adverse drug reaction,ADR)的发生情况。方法:收集2013—2016年该院上报的367例ADR报告,从患者的性别与年龄、引发ADR的给药途径、引发ADR的药物种类、ADR累及器官和(或)系统及主要临床表现等方面对24例严重的ADR进行分析。结果:24例严重的ADR报告中,男性患者略多于女性,>60岁者多见;7例(占29.16%)患者病情严重,17例(占70.83%)住院或住院时间延长。引发严重的ADR的给药途径以静脉滴注为主;引发严重的ADR病例数排序居前3位的药物种类分别为抗病原微生物药、抗肿瘤药、维生素和营养药;严重的ADR主要累及皮肤及其附件,其次为消化系统和循环系统。结论:严重的ADR的发生与多种因素相关,临床应加强用药监测,通过相关培训提高医务人员对ADR的上报意识,保证临床合理用药。
OBJECTIVE：To investigate the incidence of severe adverse drug reactions （ ADR） in Anhui Provincial Cancer Hospital （ hereinafter referred to as ＂this hospital＂） .METHODS：367 reports of ADR during 2013-2016 were collected, analysis was conducted on 24 cases of severe ADR in terms of patients ＇ genders and ages , administration routes, species of drugs inducing ADR , involved organs and （ or） systems and its clinical features .RESULTS：Among the 24 reports of severe ADR , the number of male patients was slightly more than females , most aged over 60;7 cases （29.16%） were seriously ill, 17 cases （70.83%） were in hospital or prolonged hospital stays .Intravenous drip was the main administration route inducing severe ADR;the top 3 species of drugs inducing severe ADR were respectively antimicrobial drugs , antineoplastic drugs and vitamins , nutriceuticals; the severe ADR mainly involved skin and its accessories, secondly was digestive system and circulatory system .CONCLUSIONS：The severe ADR was multi-factor related, monitoring on clinical medication needs to be reinforced , related trainings on medical staff of ADR reporting are needed to ensure clinical rational medication .
出处
《中国医院用药评价与分析》
2017年第10期1411-1412,1415,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药品不良反应
报告分析
合理用药
监测
Adverse drug reactions
Analysis on reports
Rational medication
Monitoring
