摘要
目的:通过总结和分析注射用尖吻蝮蛇血凝酶发生的不良反应,探讨其不良反应的发生的规律及临床表现,为临床提供参考。方法:对2014年1月至2017年2月首都医科大学附属北京妇产医院临床药师收集上报的使用尖吻蝮蛇血凝酶发生不良反应的报告进行回顾性分析。检索中英文数据库,对已报道不良反应的文献进行总结分析。结果:尖吻蝮蛇血凝酶发生不良反应多在用药后30 min内,不良反应可累及多个系统,可发生严重的过敏性休克反应,其结果与文献总结一致。结论:通过对尖吻蝮蛇血凝酶不良反应分析与总结,提示医护人员应在使用注射用尖吻蝮蛇血凝酶前做好评估,使用中做好监测,若发生不良反应,应及时对症处理。
Objective： To summarize the adverse reactions of heamocoagulase agkistrodon for injection, so as to probe into the regularity and clinical manifestations of ADR and to provide reference for the rational drug use. Methods： Retrospective analysis the ADR induced by heamocoagulase agkistrodon in intravenous injection occurred in Beijing Obstetrics Gynecology Hospital Affiliated to Capital Medical University from January 2014 to February 2017. And then summarized the literature in database. Results： ADR mainly occurred within 30 min after heamocoagulase agkistrodon injection and affected multiple system of the body, even including severe anaphylactic shock. The results were identical with those reported in literature. Conclusion： Through the analysis, close attention should be paid for assessment before use and for monitoring during heamocoagulase agkistrodon application. Effective rescue measures should be given in time when ADR appears.
出处
《临床药物治疗杂志》
2017年第7期40-43,共4页
Clinical Medication Journal
