摘要
目的:探讨麻杏二陈三子汤对小儿哮喘急性发作的疗效及其对免疫机制的影响。方法:选取2014年8月至2016年12月宝鸡市中医医院收治的因哮喘急性发作入院治疗的患儿90例,按照随机数表法将入组患儿分为对照组、观察组各45例。对照组患儿接受临床常规治疗,观察组患儿接受常规+麻杏二陈三子汤治疗。比较2组患儿的疗效及Th17/Treg细胞免疫、Th1/Th2细胞免疫水平的差异。结果:治疗后,观察组患儿的治疗总有效率高于对照组患儿(P<0.05);观察组患儿外周血中Th17细胞比例、Th17/Treg比值低于对照组患儿,Treg细胞比例高于对照组患儿(P<0.05);观察组患儿血清中Th1细胞因子IL-2、IFN-γ的含量高于对照组患儿,Th2细胞因子IL-4、IL-10的含量低于对照组患儿(P<0.05)。结论:麻杏二陈三子汤治疗小儿哮喘急性发作,可有效提升整体疗效、优化机体免疫功能。
Objective： To study the curative effects of Maxing Erchen Sanzi Decoction on children with acute episode of bronchial asthma and its influence on immune mechanism. Methods： A total of 90 children with acute episode of bronchial asthma who were treated in our hospital from August 2014 to December 2016 were selected and randomly divided into control group and observation group with 45 cases in each group according to random number table. Patients in control group were treated with routine treatment,and those in observation group were added Maxing Erchen Sanzi Decoction. The curative effects,the differences of Th17/Treg cell immunity and Th1/Th2 cell immunity between two groups were compared. Results： After treatment,the total efficiency in observation group was higher than that in control group（ P〈0. 05）; The peripheral blood Th17 cell proportion and Th17/Treg ratio in observation group were lower than that in control group,and the proportion of Treg cells was higher than that in control group（ P〈0. 05）; serum contents of Th1 cell factors such as IL-2 IFN-γwere higher than those in control group,and contents of Th2 cytokines such as IL-4,IL-10 were lower than those in control group（ P〈0. 05）. Conclusion： Maxing Erchen Sanzi Decoction treatment in children with acute episode of bronchial asthma can effectively improve the overall curative effects,and optimize the immune function.
出处
《世界中医药》
CAS
2017年第10期2389-2392,共4页
World Chinese Medicine
基金
2014年陕西省科技计划项目(2014KRM89)
